00302
桔霉素
from Penicillium citrinum, ≥98.0% (TLC)
别名:
桔青霉素
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关于此项目
经验公式（希尔记法）:
C13H14O5
化学文摘社编号:
分子量:
250.25
EC Number:
208-257-2
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
5282243
InChI key
CQIUKKVOEOPUDV-IYSWYEEDSA-N
InChI
1S/C13H14O5/c1-5-7(3)18-4-8-9(5)6(2)11(14)10(12(8)15)13(16)17/h4-5,7,15H,1-3H3,(H,16,17)/t5-,7-/m1/s1
SMILES string
C[C@H]1OC=C2C(O)=C(C(O)=O)C(=O)C(C)=C2[C@@H]1C
biological source
Penicillium citrinum
assay
≥98.0% (TLC)
storage temp.
2-8°C
Biochem/physiol Actions
A mycotoxin found in grains and animal feed that nephrotoxic and is a teratogen in rodents, reducing blastocyst cell number, embryonic survival, and neonatial weight and increasing fetal abnormalities. It′s cytotoxicity to cells in culture are associated with the production of reactive oxygen species, the activation of mitochondrial apoptotic pathways, and the inhibition of antiapoptotic phosphorylation pathways.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Carc. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
S M Ribeiro et al.
Cell biochemistry and function, 15(3), 203-209 (1997-10-23)
The effects of citrinin in the maintenance of the homeostasis of the reactive oxygen species in rat liver cells were evaluated. Citrinin (CTN) modifies the antioxidant enzymatic defences of cells through the inhibition of GSSG-reductase and transhydrogenase. No effect was
Wen-Hsiung Chan
The Biochemical journal, 404(2), 317-326 (2007-03-03)
The mycotoxin CTN (citrinin), a natural contaminant in foodstuffs and animal feeds, has cytotoxic and genotoxic effects on various mammalian cells. CTN is known to cause cell injury, including apoptosis, but the precise regulatory mechanisms of CTN action, particularly in
Nittin D Singh et al.
Journal of applied toxicology : JAT, 27(2), 143-151 (2006-12-23)
Dietary exposures to food pollutants such as mycotoxin(s) or pesticide(s) are most significant due to their adverse effects on the production and reproduction in animals and the human population. The present investigation was conducted to evaluate the teratogenic potential of
Terje Svingen et al.
Environmental toxicology, 32(5), 1658-1664 (2016-09-16)
Mycotoxins are fungi-born metabolites that can contaminate foods through mould-infected crops. They are a significant food/feed-safety issue across the globe and represent a substantial financial burden for the world economy. Moreover, with a changing climate and fungal biota, there is
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