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Merck
CN

00344

5-氯-2-甲基-4-异噻唑啉-3-酮 溶液

~1.2% in H2O

别名:

5-氯-2-甲基-3(2H)-异噻唑酮

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关于此项目

经验公式(希尔记法):
C4H4ClNOS
化学文摘社编号:
分子量:
149.60
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
1210149
MDL number:
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concentration

~1.2% in H2O

impurities

~0.3% 2-methyl-4-isothiazolin-3-one, ~1% magnesium chloride, ~25% magnesium nitrate

refractive index

n20/D 1.378

mp

200-230 °C

SMILES string

CN1SC(Cl)=CC1=O

InChI

1S/C4H4ClNOS/c1-6-4(7)2-3(5)8-6/h2H,1H3

InChI key

DHNRXBZYEKSXIM-UHFFFAOYSA-N

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

8B - Non-combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Britta Wareing et al.
ALTEX, 37(4), 639-651 (2020-06-11)
While the skin sensitization hazard of substances can be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA wherein
Sang S Lee et al.
The Journal of dermatology, 39(8), 677-681 (2012-05-03)
As many new cosmetic products are introduced into the market, attention must be given to contact dermatitis, which is commonly caused by cosmetics. We investigate the prevalence of preservative allergy in 584 patients with suspected cosmetic contact dermatitis at 11
Michael D Lundov et al.
Contact dermatitis, 63(3), 164-167 (2010-08-10)
Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been one of the most frequent sensitizers since the 1980s. In 2005, the use of MI alone was approved for the preservation of cosmetic and household products in the EU. Before that, MI was used in industrial
Julien Mutschler et al.
Toxicology in vitro : an international journal published in association with BIBRA, 23(3), 439-446 (2009-05-16)
Assessment of skin sensitization hazard of chemicals currently depends on in vivo methods. Considering the forthcoming European Union ban on in vivo testing of cosmetic/toiletry ingredients, the search for alternative non-animal approaches is an urgent challenge for investigators today. For
Leena Ackermann et al.
Contact dermatitis, 64(1), 49-53 (2010-12-21)
Antimicrobials constitute the second most common cause of contact allergy to cosmetics. Methylisothiazolinone (MI), previously always used together with methylchloroisothiazolinone (MCI), has recently been approved in the EU for use on its own in cosmetics and also various industrial products.

全球贸易项目编号

货号GTIN
D102202-100G04061833558379
44224904061836952761
D102202-25G04061833558386

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