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Merck
CN

01769

叶酸

别名:

叶酸, N-4-[(2-氨基-4-氧代-1,4-二氢-6-喋啶)甲氨基苯甲酰基]-L-谷氨酸, PteGlu, 维生素 M

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关于此项目

经验公式（希尔记法）:
C19H19N7O6
化学文摘社编号:
59-30-3
分子量:
441.40
UNSPSC Code:
12352209
PubChem Substance ID:
329747356
eCl@ss:
34058014
EC Number:
200-419-0
Beilstein/REAXYS Number:
100781
MDL number:
MFCD00079305

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InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

biological source

synthetic

agency

USP/NF

assay

96.0-102.0% anhydrous basis

form

powder

color

yellow

mp

250 °C

solubility

cold water: very slightly soluble 0.0016 mg/ml at 25 degrees C, boiling water: soluble 1%, 1-butanol: partially soluble, acetone: insoluble, benzene: insoluble, chloroform: insoluble, diethyl ether: insoluble, dilute HCl: soluble (Hot), ethanol: partially soluble, methanol: slightly soluble, sulfuric acid: soluble

storage temp.

2-8°C

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Application

向对照组和表现出糖尿病的妊娠大鼠中注射叶酸，以研究叶酸补充剂能否减轻糖尿病和葡萄糖诱导的大鼠胚胎畸形的发生。它还可用于合成N10-三氟乙酰基蝶酸。

Biochem/physiol Actions

叶酸（Folic acid）也称为叶酸（folate）、维生素M或维生素Bc，是水溶性维生素B9的一种形式。叶酸疗法可降低高同型半胱氨酸血症患者的精氨酸和不对称二甲基精氨酸（ADMA）血浆水平升高。叶酸在怀孕初期可作为食品补充剂降低神经管畸形的风险。

Preparation Note

叶酸溶于热的稀HCl、H2SO4和约1％的沸水中。它在甲醇中微溶，在冷水中具有非常微弱的溶解度（25°C时0.0016 mg/ml）。此外，该产物可明显溶于乙醇和丁醇中，并在乙酸、苯酚、吡啶、碱金属氢氧化物和碳酸盐的溶液中具有相对的溶解性。它不溶于丙酮、苯、醚和氯仿。

存储类别

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
BCBR2469V
BCBQ2830V
BCBM5494V
BCBP9129V
BCBP0398V

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Parri Wentzel et al.
Diabetes, 54(2), 546-553 (2005-01-29)
Maternal administration of folic acid diminishes the risk of neural tube defects (NTDs) in offspring, but whether folic acid exerts a similar effect in diabetic pregnancy is unknown. The aim was to investigate whether maldevelopment in rat embryos caused by
A Milunsky et al.
JAMA, 262(20), 2847-2852 (1989-11-24)
We examined the relation of multivitamin intake in general, and folic acid in particular, to the risk of neural tube defects in a cohort of 23,491 women undergoing maternal serum alpha-fetoprotein screening or amniocentesis around 16 weeks of gestation. Complete
Ruben M Sandoval et al.
American journal of physiology. Cell physiology, 287(2), C517-C526 (2004-04-23)
Intravital two-photon microscopy was used to follow the uptake and trafficking of fluorescent conjugates of folic acid in the rat kidney. Intravenously administered folate-linked dye molecules quickly filled the plasma volume but not cellular components of the blood. Glomerular filtration
Kirsten B Holven et al.
The British journal of nutrition, 89(3), 359-363 (2003-03-12)
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO synthase, has been suggested to be a novel risk factor for endothelial dysfunction. It has previously been reported that hyperhomocysteinaemia may be associated with impaired endothelium-dependent vasodilation and reduced plasma level of
Tihomir Tomasić et al.
Bioorganic & medicinal chemistry letters, 19(1), 153-157 (2008-11-19)
Mur ligases catalyze the biosynthesis of the UDP-MurNAc-pentapeptide precursor of peptidoglycan, an essential polymer of bacterial cell-wall. They constitute attractive targets for the development of novel antibacterial agents. Here we report on the synthesis of a series of 2,4-diaminoquinazolines, quinazoline-2,4(1H,3H)-diones
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