03716
(±)-Lisofylline
analytical standard
别名:
Lisofylline, (±)-1-(5-Hydroxyhexyl)-3,7-dimethylxanthine, 5-Hydroxy pentoxifylline, Penthydroxyfylline
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关于此项目
经验公式（希尔记法）:
C13H20N4O3
化学文摘社编号:
分子量:
280.32
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3
SMILES string
O=C1N(CCCCC(O)C)C(N(C)C2=C1N(C)C=N2)=O
InChI key
NSMXQKNUPPXBRG-UHFFFAOYSA-N
grade
analytical standard
assay
≥99.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
−20°C
Quality Level
General description
Lisofylline (LSF) is a synthetically modified methylxanthine which is known to exhibit various therapeutic properties. It is a potent anti-inflammatory agent and an antioxidant with the ability to suppress oxygen radical production. LSF is used for treating acute lung injury and also has a role in the early treatment of diabetes.
Application
Lisofylline may be used as an analytical reference standard for the determination of the analyte in rat plasma by various high-performance liquid chromatography (HPLC) based techniques.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Simultaneous estimation of lisofylline and pentoxifylline in rat plasma by high performance liquid chromatography-photodiode array detector and its application to pharmacokinetics in rat
Italiya KS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1061(1), 49-56 (2017)
Validation of a high
Walczak M, et al.
Acta Poloniae Pharmaceutica, 66(3), 215-224 (2009)
Lisofylline: a potential lead for the treatment of diabetes
Yang Z, et al.
Biochemical Pharmacology, 69(1), 1-5 (2005)
Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes
Yang Z, et al.
Biochemical and Biophysical Research Communications, 344(3), 1017-1022 (2006)
Lisofylline, a novel antiinflammatory agent, protects pancreatic $\beta$-cells from proinflammatory cytokine damage by promoting mitochondrial metabolism
Chen M, et al.
Endocrinology, 143(6), 2341-2348 (2002)
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