04704
环氧丙酰胺
analytical standard
别名:
Oxiranecarboxamide
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关于此项目
经验公式（希尔记法）:
C3H5NO2
化学文摘社编号:
分子量:
87.08
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
227-163-2
Beilstein/REAXYS Number:
227 163 2
MDL number:
产品名称
环氧丙酰胺, analytical standard
SMILES string
NC(=O)C1CO1
InChI
1S/C3H5NO2/c4-3(5)2-1-6-2/h2H,1H2,(H2,4,5)
InChI key
FMAZQSYXRGRESX-UHFFFAOYSA-N
grade
analytical standard
assay
≥95% (qNMR)
shelf life
limited shelf life, expiry date on the label
application(s)
environmental
format
neat
storage temp.
2-8°C
Quality Level
Other Notes
2008 年夏天慕尼黑理工大学的研究人员在薯片中检测到了除丙烯酰胺之外的环氧丙酰胺。环氧丙酰胺为丙烯酰胺的代谢物。
Application
Glycidamide may be used as an analytical standard for the determination of the analyte in human and animal biological samples by various chromatography techniques.
General description
Glycidamide, an active epoxide metabolite of acrylamide with potential biological activity, can be generated in vivo. Its mutagenic and genotoxic nature is well-known.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Talita Duarte-Salles et al.
Environmental health perspectives, 121(3), 374-379 (2012-12-04)
Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects
Hitesh V Motwani et al.
Journal of chromatography. A, 1218(28), 4389-4394 (2011-06-10)
Glycidamide (GA) is the epoxy metabolite of acrylamide (AA). A sensitive analytical method for quantitative measurement of GA from in vitro metabolism studies is useful in several contexts, e.g. in studies of enzyme kinetics in different species and factors influencing
Nico Watzek et al.
Chemical research in toxicology, 25(2), 381-390 (2012-01-04)
Acrylamide (AA) is formed during the heating of food and is classified as a genotoxic carcinogen. The margin of exposure (MOE), representing the distance between the bench mark dose associated with 10% tumor incidence in rats and the estimated average
Marie Pedersen et al.
Environmental health perspectives, 120(12), 1739-1745 (2012-10-25)
Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. We examined the associations between prenatal exposure to acrylamide and birth outcomes in
Hitesh V Motwani et al.
Scientific reports, 7(1), 17560-17560 (2017-12-16)
When employing metabolism studies of genotoxic compounds/metabolites and cancer tests for risk estimation, low exposure doses in humans are roughly extrapolated from high exposure doses in animals. An improvement is to measure the in vivo dose, i.e. area under concentration-time
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