04704
环氧丙酰胺
analytical standard
别名:
Oxiranecarboxamide
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关于此项目
经验公式（希尔记法）:
C3H5NO2
化学文摘社编号:
分子量:
87.08
Beilstein:
227 163 2
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
方案
≥95% (qNMR)
保质期
limited shelf life, expiry date on the label
应用
environmental
包装形式
neat
储存温度
2-8°C
SMILES字符串
NC(=O)C1CO1
InChI
1S/C3H5NO2/c4-3(5)2-1-6-2/h2H,1H2,(H2,4,5)
InChI key
FMAZQSYXRGRESX-UHFFFAOYSA-N
一般描述
Glycidamide, an active epoxide metabolite of acrylamide with potential biological activity, can be generated in vivo. Its mutagenic and genotoxic nature is well-known.
应用
Glycidamide may be used as an analytical standard for the determination of the analyte in human and animal biological samples by various chromatography techniques.
其他说明
2008 年夏天慕尼黑理工大学的研究人员在薯片中检测到了除丙烯酰胺之外的环氧丙酰胺。环氧丙酰胺为丙烯酰胺的代谢物。
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Simultaneous determination of acrylamide, its metabolite glycidamide and antipyrine in human placental perfusion fluid and placental tissue by liquid chromatography-electrospray tandem mass spectrometry
Annola K, et al.
Journal of Chromatography. B, Biomedical Applications, 876(2), 191-197 (2008)
Hans von Stedingk et al.
Chemical research in toxicology, 24(11), 1957-1965 (2011-09-03)
The knowledge about fetal exposure to acrylamide/glycidamide from the maternal exposure through food is limited. Acrylamide, glycidamide, and ethylene oxide are electrophiles and form adducts with hemoglobin (Hb), which could be used for in vivo dose measurement. In this study
Malene Outzen et al.
The British journal of nutrition, 105(9), 1381-1387 (2011-01-29)
Acrylamide (AA) is a probable human carcinogen that is formed in heat-treated carbohydrate-rich foods. The validity of FFQ to assess AA exposure has been questioned. The aim of the present cross-sectional study was to investigate dietary determinants of Hb-AA and
Anna C Vikström et al.
Toxicological sciences : an official journal of the Society of Toxicology, 119(1), 41-49 (2010-10-19)
For assessment of cancer risk from acrylamide (AA) exposure through food, the relation between intake from food in humans and the in vivo doses (area under the concentration-time curve, AUC) of AA (AUC-AA) and of its genotoxic metabolite glycidamide (GA)
Birgit Paulsson et al.
Rapid communications in mass spectrometry : RCM, 17(16), 1859-1865 (2003-07-24)
Acrylamide (AA) is a reactive compound widely used as an industrial chemical. It is also, as recently shown, present in heated foodstuffs. AA is known to cause tumors in rodents and is classified as probably carcinogenic to humans. The metabolite
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