07858
(R)-3-氨基-1-叔丁氧羰基哌啶
≥98.0% (TLC)
别名:
(R)-1-Boc-3-氨基哌啶, (R)-1-叔丁氧羰基-3-氨基哌啶
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选择尺寸
关于此项目
经验公式（希尔记法）:
C10H20N2O2
化学文摘社编号:
分子量:
200.28
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
产品名称
(R)-3-氨基-1-叔丁氧羰基哌啶, ≥98.0% (TLC)
InChI key
AKQXKEBCONUWCL-MRVPVSSYSA-N
SMILES string
CC(C)(C)OC(=O)N1CCC[C@@H](N)C1
InChI
1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1
assay
≥98.0% (TLC)
optical activity
[α]/D -28.5±2°, c = 1 in DMF
Quality Level
Application
(R)-3-Amino-1-Boc-piperidine can be used to prepare a benzoxazepine derivative named (R)-7-(3,5-dimethoxyphenyl)-N-(piperidin-3-yl)-4-propionyl-2,3,4,5-tetrahydro-1,4-benzoxazepine-9-carboxamide, a potent CBP/P300 bromodomain inhibitor.
General description
(R)-3-Amino-1-Boc-piperidine can be used as a precursor for the preparation of dipeptidyl peptidase IV inhibitors like linagliptin, alogliptin, and other antidiabetic agents.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Development of selective CBP/P300 benzoxazepine bromodomain inhibitors
Popp TA, et al.
Journal of Medicinal Chemistry, 59(19), 8889-8912 (2016)
Asymmetric synthesis of a high added value chiral amine using immobilized ω-transaminases
Petri A, et al.
Beilstein Journal of Organic Chemistry, 15(1), 60-66 (2019)
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