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Merck
CN

09668

N,N,N′,N′-四甲基脲-O-(N-琥珀酸亚胺基)六氟磷酸盐

≥99.0% (TLC/N)

别名:

N,N,N′,N′-四甲基-O-(N-琥珀酸亚胺基)脲六氟磷酸盐, HSTU

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关于此项目

经验公式(希尔记法):
C9H16F6N3O3P
化学文摘社编号:
分子量:
359.21
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
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产品名称

N,N,N′,N′-四甲基脲-O-(N-琥珀酸亚胺基)六氟磷酸盐, ≥99.0% (TLC/N)

InChI

1S/C9H16N3O3.F6P/c1-10(2)9(11(3)4)15-12-7(13)5-6-8(12)14;1-7(2,3,4,5)6/h5-6H2,1-4H3;/q+1;-1

SMILES string

F[P-](F)(F)(F)(F)F.CN(C)C(\ON1C(=O)CCC1=O)=[N+](\C)C

InChI key

STWZCCVNXFLDDD-UHFFFAOYSA-N

assay

≥99.0% (TLC/N)

form

crystals

reaction suitability

reaction type: Coupling Reactions

mp

218-221 °C (dec.)

solubility

acetonitrile: 0.5 g/mL, slightly hazy, colorless

application(s)

peptide synthesis

storage temp.

−20°C

Quality Level

Other Notes

偶联剂,用于合成肽以及形成其他酰胺。即使在水溶液中,产率依然很高

Application

Reactant for:
Synthesis of liposomal contrast agents for magnetic resonance imaging
Synthesis of thiol-reactive Cy5 derivatives
Synthesis of protein labeling molecules

General description

N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate can be used to prepare N-succinimidyl 4-[18F]fluorobenzoate ([18F]-SFB), a prosthetic group for the fluorination of biomolecules for PET imaging.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Synthesis of 18F-labeled membrane-penetrating peptide as PET tracer
Tang G and Wang X
Journal of Nuclear Medicine, 49, 97P-97P (2008)
18F-nanobody for PET imaging of HER2 overexpressing tumors
Xavier C, et al.
Nuclear Medicine and Biology, 43, 247-252 (2016)
Virginia Wycisk et al.
ChemistryOpen, 6(3), 437-446 (2017-06-24)
Herein, we present a new synthetic route to cyanine-based heterobifunctional dyes and their application as fluorescent linkers between polymers and biomolecules. The synthesized compounds, designed in the visible spectral range, are equipped with two different reactive groups for highly selective
PET imaging of macrophage mannose receptor-expressing macrophages in tumor stroma using 18F-radiolabeled camelid single-domain antibody fragments
Blykers A, et al.
Journal of Nuclear Medicine, 56, 1265-1271 (2015)
Synthesis and in vivo evaluation of p-18F-Fluorohippurate as a new radiopharmaceutical for assessment of renal function by PET
Awasthi V, et al.
Journal of Nuclear Medicine, 52, 147-153 (2011)

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