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关于此项目
经验公式(希尔记法):
C9H16F6N3O3P
化学文摘社编号:
分子量:
359.21
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
产品名称
N,N,N′,N′-四甲基脲-O-(N-琥珀酸亚胺基)六氟磷酸盐, ≥99.0% (TLC/N)
InChI
1S/C9H16N3O3.F6P/c1-10(2)9(11(3)4)15-12-7(13)5-6-8(12)14;1-7(2,3,4,5)6/h5-6H2,1-4H3;/q+1;-1
SMILES string
F[P-](F)(F)(F)(F)F.CN(C)C(\ON1C(=O)CCC1=O)=[N+](\C)C
InChI key
STWZCCVNXFLDDD-UHFFFAOYSA-N
assay
≥99.0% (TLC/N)
form
crystals
reaction suitability
reaction type: Coupling Reactions
mp
218-221 °C (dec.)
solubility
acetonitrile: 0.5 g/mL, slightly hazy, colorless
application(s)
peptide synthesis
storage temp.
−20°C
Quality Level
Other Notes
偶联剂,用于合成肽以及形成其他酰胺。即使在水溶液中,产率依然很高
Application
Reactant for:
Synthesis of liposomal contrast agents for magnetic resonance imaging
Synthesis of thiol-reactive Cy5 derivatives
Synthesis of protein labeling molecules
Synthesis of liposomal contrast agents for magnetic resonance imaging
Synthesis of thiol-reactive Cy5 derivatives
Synthesis of protein labeling molecules
General description
N,N,N′,N′-Tetramethyl-O-(N-succinimidyl)uronium hexafluorophosphate can be used to prepare N-succinimidyl 4-[18F]fluorobenzoate ([18F]-SFB), a prosthetic group for the fluorination of biomolecules for PET imaging.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
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Virginia Wycisk et al.
ChemistryOpen, 6(3), 437-446 (2017-06-24)
Herein, we present a new synthetic route to cyanine-based heterobifunctional dyes and their application as fluorescent linkers between polymers and biomolecules. The synthesized compounds, designed in the visible spectral range, are equipped with two different reactive groups for highly selective
PET imaging of macrophage mannose receptor-expressing macrophages in tumor stroma using 18F-radiolabeled camelid single-domain antibody fragments
Blykers A, et al.
Journal of Nuclear Medicine, 56, 1265-1271 (2015)
Synthesis and in vivo evaluation of p-18F-Fluorohippurate as a new radiopharmaceutical for assessment of renal function by PET
Awasthi V, et al.
Journal of Nuclear Medicine, 52, 147-153 (2011)
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