16715
Thiamphenicol
analytical standard
别名:
D-threo-2,2-Dichloro-N-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide
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关于此项目
经验公式（希尔记法）:
C12H15Cl2NO5S
化学文摘社编号:
分子量:
356.22
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
239-355-3
Beilstein/REAXYS Number:
2819542
MDL number:
产品名称
Thiamphenicol, analytical standard
InChI key
OTVAEFIXJLOWRX-NXEZZACHSA-N
InChI
1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
SMILES string
CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl
grade
analytical standard
assay
≥98.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
solubility
ethanol: 50 mg/mL, clear, colorless to faintly yellow
application(s)
clinical
format
neat
storage temp.
2-8°C
Quality Level
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Thiamphenicol may be used as a reference standard in the determination of thiamphenicol in honey using dispersive liquid-liquid microextraction (DLLME) coupled with high-performance liquid chromatography-variable wavelength detector (HPLC-VWD).
General description
Chemical structure: sulfonamide
Thiamphenicol is an analog of a broad spectrum antibiotic, chloramphenicol. It shows therapeutic effects in respiratory infections, venereal diseases and bacterial prostatitis.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Dispersive liquid--liquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for simultaneous determination of chloramphenicol and thiamphenicol in honey
Chen H, et al.
Analytica Chimica Acta, 632(1), 80-85 (2009)
[Toxicity of chloramphenicol and thiamphenicol (CAP and TAP)].
G Keiser
Haematology and blood transfusion, 21, 179-195 (1978-01-01)
D Malvy et al.
Intensive care medicine, 18(8), 485-487 (1992-01-01)
A 27-year-old woman, without compromised immunodefenses, experienced a Listeria meningoencephalitis, with brainstem symptoms. The identified agent exhibited poor susceptibility to usual effective antibiotics, except for penicillins. Knowledge of past history of an allergic reaction to beta-lactam antibiotics lead to appropriate
J Raymond et al.
Medecine tropicale : revue du Corps de sante colonial, 64(1), 33-38 (2004-07-01)
Streptococcus pneumoniae and Haemophilus influenzae are the two main pathogens responsible for bacterial respiratory tract infections. Their antimicrobial susceptibility to antibiotics like beta-lactams, macrolides or fluoroquinolones has been largely studied, while it remains less known to other antibiotics like thiamphenicol
Chloramphenicol and thiamphenicol.
J Fuglesang et al.
Antibiotics and chemotherapy, 31, 1-21 (1982-01-01)
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