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Merck
CN

16730

2-溴-2-氯-1,1,1-三氟乙烷

≥99.0% (GC)

别名:

Halothane

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关于此项目

线性分子式:
BrCH(Cl)CF3
化学文摘社编号:
151-67-7
分子量:
197.38
EC Number:
205-796-5
UNSPSC Code:
12352202
PubChem Substance ID:
329751365
Beilstein/REAXYS Number:
1736947
MDL number:
MFCD00009602

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InChI key

BCQZXOMGPXTTIC-UHFFFAOYSA-N

InChI

1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

SMILES string

FC(F)(F)C(Cl)Br

vapor pressure

4.5 psi ( 20 °C)

assay

≥99.0% (GC)

Gene Information

human ... ATP5D(513), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GLRA1(2741), GLRB(2743), GRIA1(2890), KCNK10(54207), KCNK18(338567), KCNK2(3776), KCNK3(3777), KCNK9(51305), KCNN4(3783)

bp

50.2 °C (lit.)

density

1.872 g/mL at 25 °C (lit.)

storage temp.

2-8°C

Biochem/physiol Actions

2-Bromo-2-chloro-1,1,1-trifluoroethane is an inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits the synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.
Inhalation anesthetic.

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

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T Russell et al.
Anaesthesia, 67(9), 1021-1024 (2012-06-28)
We present the case of a 20-year-old woman who developed rhabdomyolysis, disseminated intravascular coagulopathy and multi-organ failure induced by ecstasy. Following initial improvement, she developed delayed rhabdomyolysis then haloperidol-induced neuroleptic malignant syndrome, which was treated with a total of 50
Hilmi Orhan et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 18(1), 73-81 (2012-11-10)
To investigate whether lipid and protein oxidation products are elevated and correlated with routine clinical markers of hepatic and renal function in patients anesthetized with halothane, isoflurane, or sevoflurane. Urine and blood samples were collected from patient groups. Excretion of
Travis J A Craddock et al.
PloS one, 7(6), e37251-e37251 (2012-07-05)
The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuronal cytoskeleton is extremely complex, it is no wonder that a startling number of neurodegenerative disorders (including but not limited to Alzheimer's disease, Parkinson's disease and
Leigh D Plant et al.
Science signaling, 5(251), ra84-ra84 (2012-11-22)
The standing outward K(+) current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We showed that SUMOylation silenced half of IKso at the surface of cerebellar granule neurons because the underlying channels
Jason T Moore et al.
Current biology : CB, 22(21), 2008-2016 (2012-10-30)
Despite seventeen decades of continuous clinical use, the neuronal mechanisms through which volatile anesthetics act to produce unconsciousness remain obscure. One emerging possibility is that anesthetics exert their hypnotic effects by hijacking endogenous arousal circuits. A key sleep-promoting component of
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