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Merck
CN

16730

Sigma-Aldrich

2-溴-2-氯-1,1,1-三氟乙烷

≥99.0% (GC)

别名:

Halothane

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关于此项目

线性分子式:
BrCH(Cl)CF3
化学文摘社编号:
151-67-7
分子量:
197.38
Beilstein:
1736947
EC 号:
205-796-5
MDL编号:
MFCD00009602
UNSPSC代码:
12352202
PubChem化学物质编号:
329751365

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蒸汽压

4.5 psi ( 20 °C)

方案

≥99.0% (GC)

折射率

n20/D 1.369 (lit.)
n20/D 1.369

沸点

50.2 °C (lit.)

密度

1.872 g/mL at 25 °C (lit.)

储存温度

2-8°C

SMILES字符串

FC(F)(F)C(Cl)Br

InChI

1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

InChI key

BCQZXOMGPXTTIC-UHFFFAOYSA-N

基因信息

human ... ATP5D(513), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GLRA1(2741), GLRB(2743), GRIA1(2890), KCNK10(54207), KCNK18(338567), KCNK2(3776), KCNK3(3777), KCNK9(51305), KCNN4(3783)

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生化/生理作用

2-Bromo-2-chloro-1,1,1-trifluoroethane is an inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits the synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.
Inhalation anesthetic.

警示用语：

Danger

危险分类

Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

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Shinya Endo et al.
Toxicology, 319, 75-84 (2014-03-07)
MicroRNAs (miRNA) form a class of small non-coding RNA molecules that negatively regulate gene expression. Most cellular pathways are modulated by miRNAs. However, the pathophysiological role of miRNAs during drug-induced liver injury (DILI) remains largely unknown. In this study, the
Hilmi Orhan et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 18(1), 73-81 (2012-11-10)
To investigate whether lipid and protein oxidation products are elevated and correlated with routine clinical markers of hepatic and renal function in patients anesthetized with halothane, isoflurane, or sevoflurane. Urine and blood samples were collected from patient groups. Excretion of
Travis J A Craddock et al.
PloS one, 7(6), e37251-e37251 (2012-07-05)
The cytoskeleton is essential to cell morphology, cargo trafficking, and cell division. As the neuronal cytoskeleton is extremely complex, it is no wonder that a startling number of neurodegenerative disorders (including but not limited to Alzheimer's disease, Parkinson's disease and
William R Proctor et al.
Hepatology (Baltimore, Md.), 57(5), 2026-2036 (2012-12-15)
Drug-induced liver injury (DILI) is a major health issue, as it remains difficult to predict which new drugs will cause injury and who will be susceptible to this disease. This is due in part to the lack of animal models
Albert Quintana et al.
PloS one, 7(8), e42904-e42904 (2012-08-23)
Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABA(A) and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role of these receptors
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