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Merck
CN

17755

4-硼-L-苯丙氨酸

≥95.0% (HPLC)

别名:

4-二羟基氧硼基-L-苯丙氨酸, L-BPA

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关于此项目

经验公式(希尔记法):
C9H12BNO4
化学文摘社编号:
分子量:
209.01
UNSPSC Code:
12352209
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4458616
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产品名称

4-硼-L-苯丙氨酸, ≥95.0% (HPLC)

InChI

1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1

SMILES string

N[C@@H](Cc1ccc(cc1)B(O)O)C(O)=O

InChI key

NFIVJOSXJDORSP-QMMMGPOBSA-N

assay

≥95.0% (HPLC)

storage temp.

2-8°C

Quality Level

Application

4-二羟硼基-L-苯基丙氨酸可用作固相多肽合成的砌块。它还可用于通过钯作为催化剂进行Suzuki交叉偶联反应来合成取代三嗪衍生物作为潜在色氨酸羟化酶抑制剂。

Other Notes

酪氨酸类似物;用于通过硼中子俘获疗法治疗黑色素瘤细胞

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

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Romina F Aromando et al.
Oral oncology, 46(5), 355-359 (2010-03-24)
Mast cell (MC) activation in the hamster cheek pouch cancerization model is associated with the increase in tumor cell proliferation, mediated in turn by tryptase, a protease released from mast cell granules after activation. Tryptase induces tumor cell proliferation through
Tsubasa Watanabe et al.
BMC cancer, 16(1), 859-859 (2016-11-09)
Boron neutron capture therapy (BNCT) is a cellular-level particle radiation therapy that combines the selective delivery of boron compounds to tumour tissue with neutron irradiation. L-p-Boronophenylalanine (L-BPA) is a boron compound now widely used in clinical situations. Determination of the
W Yang et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 67(7-8 Suppl), S328-S331 (2009-05-27)
In the present report we have summarized studies carried out over the past five years on molecular targeting of the epidermal growth factor receptor (EGFR) and its mutant isoform, EFGRvIII, for BNCT of genetically engineered F98 rat gliomas, expressing either
Makoto Shirakawa et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 67(7-8 Suppl), S88-S90 (2009-05-19)
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron
The preparation of solid-supported peptide boronic acids derived from 4-borono-L-phenylalanine and their affinity for alizarin
Duggan PJ and Offermann DA
Australian Journal of Chemistry, 60(11), 829-834 (2007)

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