17755
4-硼-L-苯丙氨酸
≥95.0% (HPLC)
别名:
4-二羟基氧硼基-L-苯丙氨酸, L-BPA
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选择尺寸
关于此项目
经验公式（希尔记法）:
C9H12BNO4
化学文摘社编号:
分子量:
209.01
UNSPSC Code:
12352209
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4458616
产品名称
4-硼-L-苯丙氨酸, ≥95.0% (HPLC)
InChI
1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1
SMILES string
N[C@@H](Cc1ccc(cc1)B(O)O)C(O)=O
InChI key
NFIVJOSXJDORSP-QMMMGPOBSA-N
assay
≥95.0% (HPLC)
storage temp.
2-8°C
Quality Level
Application
4-二羟硼基-L-苯基丙氨酸可用作固相多肽合成的砌块。它还可用于通过钯作为催化剂进行Suzuki交叉偶联反应来合成取代三嗪衍生物作为潜在色氨酸羟化酶抑制剂。
Other Notes
酪氨酸类似物；用于通过硼中子俘获疗法治疗黑色素瘤细胞
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
T Fujimoto et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 69(12), 1713-1716 (2011-03-01)
Clear cell sarcoma (CCS), a rare malignant tumor with a predilection for young adults, is of poor prognosis. Recently however, boron neutron capture therapy (BNCT) with the use of p-borono-L-phenylalanine (BPA) for malignant melanoma has provided good results. CCS also
Makoto Shirakawa et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 67(7-8 Suppl), S88-S90 (2009-05-19)
We aimed at securing sufficient concentrations of (10)B in boron neutron capture therapy (BNCT) by developing a new drug delivery system. We have designed and developed a novel lipid analog and succeeded in using it to develop the new boron
Tsubasa Watanabe et al.
BMC cancer, 16(1), 859-859 (2016-11-09)
Boron neutron capture therapy (BNCT) is a cellular-level particle radiation therapy that combines the selective delivery of boron compounds to tumour tissue with neutron irradiation. L-p-Boronophenylalanine (L-BPA) is a boron compound now widely used in clinical situations. Determination of the
The preparation of solid-supported peptide boronic acids derived from 4-borono-L-phenylalanine and their affinity for alizarin
Duggan PJ and Offermann DA
Australian Journal of Chemistry, 60(11), 829-834 (2007)
Romina F Aromando et al.
Oral oncology, 46(5), 355-359 (2010-03-24)
Mast cell (MC) activation in the hamster cheek pouch cancerization model is associated with the increase in tumor cell proliferation, mediated in turn by tryptase, a protease released from mast cell granules after activation. Tryptase induces tumor cell proliferation through
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