17755
4-硼-L-苯丙氨酸
≥95.0% (HPLC)
别名:
4-二羟基氧硼基-L-苯丙氨酸, L-BPA
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关于此项目
经验公式（希尔记法）:
C9H12BNO4
CAS Number:
分子量:
209.01
Beilstein:
4458616
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.21
质量水平
方案
≥95.0% (HPLC)
储存温度
2-8°C
SMILES字符串
N[C@@H](Cc1ccc(cc1)B(O)O)C(O)=O
InChI
1S/C9H12BNO4/c11-8(9(12)13)5-6-1-3-7(4-2-6)10(14)15/h1-4,8,14-15H,5,11H2,(H,12,13)/t8-/m0/s1
InChI key
NFIVJOSXJDORSP-QMMMGPOBSA-N
应用
4-二羟硼基-L-苯基丙氨酸可用作固相多肽合成的砌块。它还可用于通过钯作为催化剂进行Suzuki交叉偶联反应来合成取代三嗪衍生物作为潜在色氨酸羟化酶抑制剂。
其他说明
酪氨酸类似物；用于通过硼中子俘获疗法治疗黑色素瘤细胞
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Rolf F Barth
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 67(7-8 Suppl), S3-S6 (2009-05-27)
Over the past 25 years research on boron neutron capture therapy (BNCT) has progressed relatively slowly but steadily with the greatest progress in the field of clinical studies. These specifically have included the use of BNCT to treat a variety
Andrea Monti Hughes et al.
Oral oncology, 47(11), 1017-1022 (2011-08-16)
Given the clinical relevance of locoregional recurrences in head and neck cancer, we developed a novel experimental model of premalignant tissue in the hamster cheek pouch for long-term studies and demonstrated the partial inhibitory effect of a single application of
Y C Lin et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 69(12), 1728-1731 (2011-03-12)
This study attempted to increase the boron uptake of human head and neck carcinoma SAS cells for BNCT by using a gamma dose of 0.1 Gy for combined treatment. Intracellular boron concentrations in 25 μgB/mL medium of BPA treated and
Maria Alejandra Dagrosa et al.
International journal of radiation oncology, biology, physics, 79(1), 262-268 (2010-10-12)
DNA lesions produced by boron neutron capture therapy (BNCT) and those produced by gamma radiation in a colon carcinoma cell line were analyzed. We have also derived the relative biologic effectiveness factor (RBE) of the neutron beam of the RA-3-
Yuko Kinashi et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 163, 109204-109204 (2020-06-21)
Temozolomide (TMZ) is a DNA-alkylating agent used for chemo-radiotherapy of glioblastoma, which is also a target cancer for boron neutron capture therapy (BNCT). Although the DNA-repair enzyme O6-methylguanine DNA methyltransferase (MGMT) and the tumor suppressor p53 are mutated in some
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