InChI key
DHUYKLYJBKXDBM-UHFFFAOYSA-N
InChI
1S/C7H5Cl2NO5S/c8-4-2-5(9)6(16(13,14)15-10)1-3(4)7(11)12/h1-2H,10H2,(H,11,12)
form
powder, powder with small lumps
specific activity
≥150 U/mg protein (protein ca. 40%)
mol wt
107 kDa by gel filtration, 57 kDa by SDS-PAGE
shipped in
wet ice
storage temp.
−20°C
General description
牛肝脏中的蛋白质二硫键异构酶 (PDI) 是一种分子量为 107 kDa 的同源二聚体（凝胶过滤），已报告单体的分子量为 57 kDa (SDS-PAGE)。该酶是总碳水化合物含量为 12% 的糖蛋白，由 4.6% 的甘露糖、2.5% 的半乳糖、1.4% 的 NANA 和 3.5% 的 2-乙酰胺基-2-脱氧葡萄糖组成。
Other Notes
1 unit corresponds to the amount of enzyme, which, in a glutathione-dithiothreitol-system, causes a change of absorbance of 0.001 per minute at pH 4.0 and 25°C.
Enzyme that accelerates the exchange reaction between disulfide bridges in proteins
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Pryank Patel et al.
Journal of molecular biology, 425(5), 929-943 (2013-01-01)
Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion. These normal intracellular and abnormal extracellular roles can be attributed to the multidomain structure of AGR2.
Pamela A Wearsch et al.
Methods in molecular biology (Clifton, N.J.), 960, 67-79 (2013-01-19)
The stability of the MHC (major histocompatibility complex) class I peptide repertoire is optimized during assembly in the endoplasmic reticulum (ER) and depends on the collective function of components of the peptide-loading complex (PLC). The chaperone-like molecule tapasin is the
Zegbeh Z Kpadeh et al.
Journal of bacteriology, 195(8), 1825-1833 (2013-02-26)
The extracytoplasmic assembly of the Dot/Icm type IVb secretion system (T4SS) of Legionella pneumophila is dependent on correct disulfide bond (DSB) formation catalyzed by a novel and essential disulfide bond oxidoreductase DsbA2 and not by DsbA1, a second nonessential DSB
Louise H Boyle et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(9), 3465-3470 (2013-02-13)
Tapasin is an integral component of the peptide-loading complex (PLC) important for efficient peptide loading onto MHC class I molecules. We investigated the function of the tapasin-related protein, TAPBPR. Like tapasin, TAPBPR is widely expressed, IFN-γ-inducible, and binds to MHC
Joohyun Ryu et al.
Biochemical and biophysical research communications, 430(2), 610-615 (2012-12-12)
Anterior Gradient 2 (AGR2), an ER stress-inducible protein, has been reported to be localized in endoplasmic reticulum (ER) and its level is elevated in numerous metastatic cancers. Recently, it has been demonstrated that AGR2 is involved in the control of
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