21186
钙离子载体 III
Selectophore™, function tested
别名:
钙离子载体A23187, 卡利霉素, 抗生素A 23187
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关于此项目
经验公式（希尔记法）:
C29H37N3O6
化学文摘社编号:
分子量:
523.62
UNSPSC Code:
26111700
NACRES:
NB.61
PubChem Substance ID:
EC Number:
258-084-1
Beilstein/REAXYS Number:
1096801
MDL number:
InChI key
HIYAVKIYRIFSCZ-CYEMHPAKSA-N
InChI
1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
SMILES string
[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
description
for ion-selective electrodes
product line
Selectophore™
form
solid
quality
function tested
antibiotic activity spectrum
Gram-positive bacteria, fungi
mode of action
cell membrane | interferes
storage temp.
2-8°C
Quality Level
General description
若要了解更多信息，请访问传感器应用程序门户。
钙离子载体 III (Calimycin；CA) 是一种二价阳离子离子载体。它具有沿浓度梯度跨膜转运 ca2+ 的能力。
Application
用钙离子拮抗剂 (CA) 对豚鼠离体灌流心房的正性、变力和变时能力进行了研究。它也可用于刺激和测量红细胞 Ca 2 + 依赖性 K + 通道 K + 外流。
离子载体对Ca2+具有高度选择性。 增强对NMDA的反应，而不是使君子氨酸。 在细胞培养中，通过钙调素依赖的构成型一氧化氮合酶刺激一氧化氮的产生。
钙离子载体 III 可用于基于离子载体的钙离子选择性电导微传感器，用于检测水溶液中的钙离子。研究表明，在 NIH3T3 和大鼠 1-成纤维细胞培养物中，钙离子载体 III 和毒胡萝卜素在治疗初期可增加肝脏生物钟基因 Per1 的表达。
Packaging
无底玻璃瓶。内容物在插入的熔锥内。
Other Notes
用于 Ca2+ 和 Mg2+ 光化学传感器的制作
Legal Information
Selectophore is a trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
H M Himmel et al.
Basic research in cardiology, 83(2), 167-175 (1988-03-01)
The inotropic and chronotropic effects of the calcium ionophore A23187 (calimycin = CA) in isolated, superfused, electrically driven, auxotonically contracting left and spontaneously beating right guinea-pig atria were examined at different Ca2+ concentrations. 10(-6) to 10(-5) mol/l CA shows significantly
P Lijnen et al.
British journal of industrial medicine, 48(6), 392-398 (1991-06-01)
The effects of cadmium (Cd2+) on Na+,K(+)-ATPase in disrupted human erythrocyte membranes and on various transmembrane Na+ and K+ transport systems in intact erythrocyte suspensions were studied. Cadmium2+ inhibited the erythrocyte Na+,K(+)-ATPase enzyme with a 50% inhibition at a Cd2+
K. Suzuki et al.
Analytical Chemistry, 61, 382-382 (1989)
Intracellular calcium mobilization induces period genes via MAP kinase pathways in NIH3T3 cells
Oh-hashi K, et al.
Febs Letters, 516(1-3), 101-105 (2002)
Gianni Francesco Guidetti et al.
The Biochemical journal, 453(1), 115-123 (2013-04-23)
In blood platelets the small GTPase Rap1b is activated by cytosolic Ca2+ and promotes integrin αIIbβ3 inside-out activation and platelet aggregation. cAMP is the major inhibitor of platelet function and antagonizes Rap1b stimulation through a mechanism that remains unclear. In
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