产品名称
醋酸邻苯二甲酸纤维素,
SMILES string
O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1COC(=O)C)O)OC(=O)c4c(cccc4)C(=O)O)O)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)OC(=O)c3c(cccc3)C(=O)O)O)COC(=O)C
InChI
1S/C32H34O19/c1-13(33)45-11-19-21(35)25(49-29(42)17-9-5-3-7-15(17)27(38)39)23(37)32(48-19)51-24-20(12-46-14(2)34)47-31(44)26(22(24)36)50-30(43)18-10-6-4-8-16(18)28(40)41/h3-10,19-26,31-32,35-37,44H,11-12H2,1-2H3,(H,38,39)(H,40,41)/t19-,20-,21-,22+,23-,24-,25+,26-,31-,32+/m1/s1
InChI key
DMNFZTKVDDFCQE-WJXNTJCASA-N
form
powder
technique(s)
LPLC: suitable
matrix
acetylated cellulose
matrix active group
phthalate
capacity
1.0 meq/mL
separation technique
reversed phase
Quality Level
General description
醋酸纤维素邻苯二甲酸酯（CAP）是一种灭活性病毒（STD）病原体（如 HIV-1）的杀微生物剂。CAP 已用于片剂和胶囊的肠溶膜包衣。
Application
CAP 用作制备假乳胶的稳定剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A Robert Neurath et al.
BMC infectious diseases, 3, 27-27 (2003-11-18)
Cellulose acetate phthalate (CAP) has been used for several decades in the pharmaceutical industry for enteric film coating of oral tablets and capsules. Micronized CAP, available commercially as "Aquateric" and containing additional ingredients required for micronization, used for tablet coating
D Quintanar-Guerrero et al.
International journal of pharmaceutics, 188(2), 155-164 (1999-10-16)
Pseudolatexes were obtained by a new process based on an emulsification-diffusion technique involving partially water-miscible solvents. The preparation method consisted of emulsifying an organic solution of polymer (saturated with water) in an aqueous solution of a stabilizing agent (saturated with
A Robert Neurath et al.
BMC infectious diseases, 2, 6-6 (2002-05-02)
Cellulose acetate phthalate (CAP), a promising candidate microbicide for prevention of sexual transmission of the human immunodeficiency virus type 1 (HIV-1) and other sexually transmitted disease (STD) pathogens, was shown to inactivate HIV-1 and to block the coreceptor binding site
James C DiNunzio et al.
Molecular pharmaceutics, 5(6), 968-980 (2009-05-13)
Amorphous engineered particle compositions of itraconazole (ITZ) and potential concentration enhancing polymers, cellulose acetate phthalate (CAP) and polyvinyl acetate phthalate (PVAP), were produced by ultra-rapid freezing to investigate the effect of these polymers on the bioavailability of ITZ solid dispersions.
C J Lacey et al.
International journal of STD & AIDS, 21(10), 714-717 (2010-12-09)
We carried out a phase 1 trial of a candidate vaginal microbicide gel against HIV-1 and other sexually transmitted diseases, which contained cellulose acetate 1,2-benzenedicarboxylate (also known as cellulose acetate phthalate) in a glycerol-based vehicle. We had to terminate the
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