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安全信息

22632

Sigma-Aldrich

奎宁 盐酸盐 二水合物

tested according to Ph. Eur.

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别名:
奎宁盐酸盐
经验公式（希尔记法）:
C20H24N2O2 · HCl · 2H2O
CAS号:
6119-47-7
分子量:
396.91
Beilstein:
6112655
EC 号:
205-001-1
MDL编号:
MFCD00151248
PubChem化学物质编号:
329752329
NACRES:
NA.25

Agency

USP/NF
tested according to Ph. Eur.

质量水平

100

形式

solid

溶解性

water: soluble 0.25 mg in 5 ml

应用

pharmaceutical (small molecule)

SMILES字符串

O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1

InChI key

MPQKYZPYCSTMEI-FLZPLBAKSA-N

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应用

Quinine hydrochloride dehydrate has been used for fluorescent in situ detection of quinine in cinchona bark using UV resonance raman spectroscopy. It has also been used as a actinometric system to measure the light-induced changes in ruthenium anticancer agent, NAMI-A.

生化/生理作用

Quinine is a very effective anti-malarial treatment but is considered toxic for routine treatment due to the development of drug resistance in the malarial parasites. It acts as blood schizonticide.Quinine reportedly blocks the membrane conductance of potassium in enteric neurons.

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险声明

H302 - H317 - H334

危险分类

Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

监管及禁止进口产品

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Is alkylation the main mechanism of action of the antimalarial drug artemisinin?.
Robert A and Meunier B
Chemical Society Reviews, 273-274 (1998)
E Cherubini et al.
British journal of pharmacology, 83(1), 3-5 (1984-09-01)
Quinine (100 microM) abolished the slow calcium-dependent afterhyperpolarization which occurs after an action potential in some neurones of the guinea-pig myenteric and submucous plexus. This occurred without any effect on the amplitude or time course of the action potential itself
D A Warrell
Journal of the Royal Society of Medicine, 82 Suppl 17, 44-50 (1989-01-01)
In the treatment of severe Plasmodium falciparum infection antimalarial drugs should, ideally, be given by controlled rate intravenous infusion until the patient is able to swallow tablets. In cases where infection has been acquired in a chloroquine resistant area, and
Torsten Frosch et al.
The journal of physical chemistry. B, 111(16), 4171-4177 (2007-03-31)
Deep UV resonance Raman micro-spectroscopy (lambda(exc) = 244 nm) was applied for a highly sensitive, selective, and gentle localization of the antimalarial quinine in situ in cinchona bark. The high potential of the method was demonstrated by the detection of
Marjan Bouma et al.
Journal of pharmaceutical and biomedical analysis, 30(4), 1287-1296 (2002-11-01)
NAMI-A is a novel ruthenium complex with selective activity against metastases currently in Phase I clinical trials in The Netherlands. The photostability of this new agent in solid state and in solution has been investigated utilizing a stability-indicating reversed-phase high
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