23125
苯丁酸氮芥
purum, ≥98.0% (T)
别名:
4- [双(2-氯乙基)氨基]苯丁酸, 4-(4-[2-(2-氯乙基)氨基]苯基)丁酸
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关于此项目
经验公式（希尔记法）:
C14H19Cl2NO2
化学文摘社编号:
分子量:
304.21
EC Number:
206-162-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
999011
MDL number:
grade
purum
assay
≥98.0% (T)
mp
65-70 °C
storage temp.
2-8°C
SMILES string
OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl
InChI
1S/C14H19Cl2NO2/c15-8-10-17(11-9-16)13-6-4-12(5-7-13)2-1-3-14(18)19/h4-7H,1-3,8-11H2,(H,18,19)
InChI key
JCKYGMPEJWAADB-UHFFFAOYSA-N
Gene Information
human ... CYP2D6(1565)
Other Notes
Alkylating antitumor agent, can be covalently coupled to monoclonal anticarcinoembryonic antigen
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
B Cortés et al.
Dermatology (Basel, Switzerland), 225(4), 320-325 (2012-12-22)
Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease and is associated with an increased mortality. The end points of our study were to evaluate the mortality rate in a retrospective cohort of BP patients followed up to
L.G. Bernier et al.
Protides Biol. Fluid Proc. Colloq., 31, 787-787 (1983)
Melissa Millard et al.
Journal of medicinal chemistry, 56(22), 9170-9179 (2013-10-24)
Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents. Importantly, cancer cells have higher intrinsic mitochondrial membrane potential (Δψmt) than