25895
氯贝丁酯
≥98.0% (GC)
别名:
氯贝特
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关于此项目
经验公式（希尔记法）:
C12H15ClO3
化学文摘社编号:
分子量:
242.70
EC Number:
211-277-4
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
1913459
MDL number:
assay
≥98.0% (GC)
refractive index
n20/D 1.503
density
1.137 g/mL at 20 °C
SMILES string
CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
InChI
1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI key
KNHUKKLJHYUCFP-UHFFFAOYSA-N
Gene Information
human ... PPARA(5465)
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Luz Ibarra-Lara et al.
Journal of cardiovascular pharmacology, 60(4), 323-334 (2012-06-14)
Peroxisome proliferator-activated receptors (PPAR) play a critical physiological role in energy homeostasis, in inflammation, and a protective role in cardiovascular function. We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPARα) stimulation on ischemic myocardium on myocardial morphology
Leigh V Panlilio et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(8), 1838-1847 (2012-03-29)
Experimental drugs that activate α-type peroxisome proliferator-activated receptors (PPARα) have recently been shown to reduce the rewarding effects of nicotine in animals, but these drugs have not been approved for human use. The fibrates are a class of PPARα-activating medications
Fabio Penna et al.
PloS one, 7(9), e45327-e45327 (2012-10-03)
Differently from the antiapoptotic action most commonly assigned to peroxisome proliferators (PPs), we demonstrated that some of them, clofibrate (CF) in particular, display clearcut apoptogenic properties on rat hepatoma cell lines. We and others could confirm that CF as well
Fekadu Yadetie et al.
BMC genomics, 13, 55-55 (2012-02-04)
Animals have developed extensive mechanisms of response to xenobiotic chemical attacks. Although recent genome surveys have suggested a broad conservation of the chemical defensome across metazoans, global gene expression responses to xenobiotics have not been well investigated in most invertebrates.
Ganesaratnam K Balendiran et al.
Journal of pharmaceutical sciences, 101(4), 1555-1569 (2012-01-17)
Isopropyl 2-[4-(4-chlorobenzoyl)-phenoxy]-2-methylpropanoic acid and isopropyl 2-(4-chlorophenoxy)-2-methylpropanoate, also known as fenofibrate and isopropyl (iPr) clofibrate, are hypolipidemic agents of the fibrate family. In a previously reported triclinic structure of fenofibrate (polymorph I), the methyl groups of the iPr moiety are located
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