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Merck
CN

26454

硬脂酸镁

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

别名:

十八酸 镁盐

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关于此项目

线性分子式:
[CH3(CH2)16CO2]2Mg
化学文摘社编号:
557-04-0
分子量:
591.24
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
57648176
EC Number:
209-150-3
Beilstein/REAXYS Number:
3919702
MDL number:
MFCD00036391

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产品名称

硬脂酸镁, puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

InChI key

HQKMJHAJHXVSDF-UHFFFAOYSA-L

InChI

1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2

SMILES string

CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC

grade

puriss.

assay

≥40% stearic acid basis (GC)
≥90% stearic and palmitic acid basis
4.0-5.0% Mg basis (calc on dry sub.)

quality

meets analytical specification of Ph. Eur., BP

impurities

acidity or alkalinity, complies
 microbiological impurity, in accordance
 residual solvents, complies

loss

≤6.0% loss on drying, 105 °C

mp

200 °C (lit.)

acid value

195‑210(fatty acid)

solubility

alcohol: insoluble
diethyl ether: insoluble
water: insoluble

anion traces

chloride (Cl-): ≤1000 mg/kg
sulfate (SO42-): ≤5000 mg/kg

cation traces

Cd: ≤3 mg/kg
Ni: ≤5 mg/kg
Pb: ≤10 mg/kg

suitability

in accordance for fatty acid composition
passes test for identity

application(s)

pharmaceutical (small molecule)

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相关类别

Application

硬脂酸镁已被用作片剂和胶囊润滑剂。也用于制备微囊。

Biochem/physiol Actions

硬脂酸镁是硬脂酸的镁盐，具有润滑性能，因此在将化学粉末压制成固体片剂时可防止成分粘在制造设备上。用硬脂酸镁干包衣可改善流动性、改善流动性和润滑效果、可压片性以及不受抑制的溶出度。

存储类别

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SDBB3898
SDBB3896
SDBB1187
SDBB1188
STBL2018

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M J Amorim et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 39-44 (2001-07-05)
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Journal of Raman Spectroscopy, 40 (2008)
A Kluk et al.
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Minitablets are a novel, multi-compartment solid drug formulation, particularly intended for children between 1 and 6 years of age. Available literature shows that even infants are capable of swallowing a single minitablet. In this study, we have explored the level
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International journal of pharmaceutics, 469(1), 94-101 (2014-04-22)
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International journal of biological macromolecules, 72, 1228-1236 (2014-12-03)
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