Name: 地塞米松
Brand: SIAL

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About This Item

经验公式（希尔记法）:

C₂₂H₂₉FO₅

CAS Number:

50-02-2

分子量:

392.46

Beilstein:

2066651

EC 号:

200-003-9

MDL编号:

MFCD00064136

UNSPSC代码:

41116107

PubChem化学物质编号:

329753755

NACRES:

NA.21

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Agency

USP/NF
tested according to Ph. Eur.

质量水平

100

方案

99.6%

表单

solid

mp

262-264 °C (lit.)

溶解性

water: soluble 10mg/100 ml at 25 °C
acetone: very slightly soluble
alcohol: very slightly soluble
chloroform: slightly soluble
diethyl ether: very slightly soluble
dioxane: very slightly soluble
methanol: very slightly soluble

应用

pharmaceutical (small molecule)

SMILES字符串

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

基因信息

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

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应用

Dexamethasone has been used as a DMEM medium supplement utilized in osteogenesis. It has also been used as an alpha-MEM medium supplement to initiate adipogenic differentiation. Additionally, it has also been used to study apoptosis, cell signaling pathways and gene expression.

生化/生理作用

糖皮质激素抗炎剂

糖皮质激素抗炎剂。调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。

Dexamethasone is a glucocorticoid anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Additionally, dexamethasone inhibits the induction of nitric oxide synthase. It induces apoptosis by initiating the initial cleavage of DNA into high molecular weight fragments.