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关于此项目
经验公式(希尔记法):
C13H14N2
化学文摘社编号:
分子量:
198.26
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
202-974-4
Beilstein/REAXYS Number:
474706
InChI key
YBRVSVVVWCFQMG-UHFFFAOYSA-N
InChI
1S/C13H14N2/c14-12-5-1-10(2-6-12)9-11-3-7-13(15)8-4-11/h1-8H,9,14-15H2
SMILES string
Nc1ccc(Cc2ccc(N)cc2)cc1
grade
analytical standard
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
Quality Level
application(s)
cleaning products
cosmetics
food and beverages
personal care
format
neat
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General description
4,4′-Diaminodiphenylmethane (MDA) is an aromatic diamine, which finds industrial applications as a precursor in the manufacturing of polyurethane products, isocyanates, polyisocyanates, etc. It is also used as a hardener in the production of epoxy resins and elastomers.
4,4′-Diaminodiphenylmethane is a curing agent for epoxy resins. It is prepared from formaldehyde aniline when heated with aniline hydrochloride and aniline.
This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)
Application
4,4′-Diaminodiphenylmethane is used as an analytical reference standard for the quantification of the analyte in the following:
It is reported to be used in the synthesis of amino modified multi-walled carbon nanotubes/polydimethylsiloxane, which serves as a coating for the stir bar sorptive extraction (SBSE) of phenols in environmental samples, followed by analysis using high performance liquid chromatography with ultraviolet detection (HPLC-UV).
- Urine samples using gas-chromatography coupled to mass spectrometry (GC-MS).
- Hepatic microsomal incubation mixture from rabbits using high-performance liquid chromatography-plasma spray mass spectrometry (HPLC-PSP-MS), offline HPLC with fast atom bombardment mass spectrometry (FAB-MS) and fast atom bombardment tandem mass spectrometry (FAB-MS/MS).
It is reported to be used in the synthesis of amino modified multi-walled carbon nanotubes/polydimethylsiloxane, which serves as a coating for the stir bar sorptive extraction (SBSE) of phenols in environmental samples, followed by analysis using high performance liquid chromatography with ultraviolet detection (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 1B - Muta. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 1
target_organs
Liver, Liver,eye - retina
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
429.8 °F - closed cup
flash_point_c
221 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
4, 4'-Diaminodiphenylmethane.
Gooch, Jan W.
Encyclopedic Dictionary of Polymers, 204-205 (2011)
Amino modified multi-walled carbon nanotubes/polydimethylsiloxane coated stir bar sorptive extraction coupled to high performance liquid chromatography-ultraviolet detection for the determination of phenols in environmental samples
Journal of Chromatography A, 1300(42), 165-172 (2013)
Identification of metabolites of 4, 4'-diaminodiphenylmethane (methylene dianiline) using liquid chromatographic and mass spectrometric techniques
Journal of Chromatography. B, Biomedical Sciences and Applications, 583(1), 63-76 (1992)
Characterization of biliary conjugates of 4, 4?-methylenedianiline in male versus female rats
Toxicology and Applied Pharmacology, 232(2), 190-202 (2008)
Hexamethylene diisocyanate, 2, 4?toluene diisocyanate, 2, 6?toluene diisocyanate, isophorone diisocyanate and 4, 4??methylene diphenyl diisocyanate?Determination of hexamethylenediamine, 2, 4?toluenediamine, 2, 6?toluenediamine, isophoronediamine and 4, 4??methylenedianiline in urine using gas chromatography?mass spectrometry [Biomonitoring Methods, 2017]
The MAK?Collection for Occupational Health and Safety: Annual Thresholds and Classifications for the Workplace, 2(3), 1415-1435 (2002)
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