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Merck
CN

31679

氯丙嗪 盐酸盐

VETRANAL®, analytical standard

别名:

2-氯-10-(3-二甲氨基丙基)吩噻嗪 盐酸盐, CPZ, 氯普马嗪

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关于此项目

经验公式（希尔记法）:
C17H19ClN2S · HCl
化学文摘社编号:
69-09-0
分子量:
355.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329753883
EC Number:
200-701-3
Beilstein/REAXYS Number:
3779989
MDL number:
MFCD00012654

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产品名称

氯丙嗪 盐酸盐, VETRANAL®, analytical standard

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

SMILES string

Cl[H].CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

Gene Information

human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)

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相关类别

Application

CPZ可以作为标准品，通过化学计量学方法[例如经典最小二乘法（CLS）、主成分回归（PCR）和偏最小二乘法（PLS）]在玻璃碳电极上对抗精神病药物进行测定。
在血红蛋白和过氧化物酶的微量测定中替代联苯胺、邻联茴香胺和邻联甲苯胺。
有关合适仪器技术的更多信息，请参考产品′分析证书。如需进一步支持，请联系技术服务。

Biochem/physiol Actions

吩噻嗪类抗精神病药;D2 多巴胺受体拮抗剂，H1 组胺受体拮抗剂;抑制钙调蛋白依赖性环核苷酸磷酸二酯酶和一氧化氮合成酶的活化。
氯丙嗪表现出对白血病细胞的细胞毒性和抗增殖活性，但是不会影响正常淋巴细胞的活力。

General description

盐酸氯丙嗪（CPZ）是一种抗精神病药物，属于吩噻嗪类抗精神病药组。它可用于治疗精神或人格障碍。

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN8840
BCCF9060
BCBV3536
BCBS3655V

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In recent years, evidence that sensitization of primary afferent nociceptors is an important event associated with chronic pain has been accumulating. The present study aimed to evaluate the participation of the prostaglandin and sympathetic components in the long-lasting sensitization of
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The extrapolation of in vitro to in vivo toxicity data is a challenge. Differences in sensitivity between cell systems may be due to intrinsic properties of the cell but also because of differences in exposure. In this study, the cytotoxicity
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