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Merck
CN

32071

萘夫西林钠盐 钠盐

VETRANAL®, analytical standard

别名:

(2S,5R,6R)-6-{[(2-Ethoxy-1-naphthalenyl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt, 6-(2-Ethoxy-1-naphthamido)penicillin sodium salt

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关于此项目

经验公式（希尔记法）:
C21H21N2NaO5S
化学文摘社编号:
985-16-0
分子量:
436.46
MDL number:
MFCD00056863
UNSPSC Code:
41116107
EC Number:
213-574-4
NACRES:
NA.24

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SMILES string

[Na+].S1[C@H]2N([C@H](C1(C)C)C(=O)O)C(=O)[C@H]2\N=C(/[O-])\c3c4c(ccc3OCC)cccc4

InChI key

AYAPZOUDXCDGIF-FRFVDRIFSA-M

InChI

1S/C21H22N2O5S.Na/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);/q;+1/p-1/t15-,16+,19-;/m1./s1

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

Quality Level

100

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相关类别

General description

Chemical structure: β-lactam
Nafcillin is a penicillin antibiotic used mostly in treating mastitis of cows.

Application

Nafcillin sodium salt (NF-PC) has been used as working standard in HPLC analysis to determine β-lactam antibiotics from milk samples and in LC–MS–MS analysis to determine NF-PC in bovine tissues.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCK5973
BCCF5669
BCCD2816
BCCC5791
BCBV6202

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M Shawn Riser et al.
The Annals of pharmacotherapy, 44(11), 1832-1835 (2010-10-21)
To report a case of methicillin-sensitive Staphylococcus aureus (MSSA) bacteremia with suspected MSSA meningitis treated with high-dose daptomycin assessed with concurrent serum and cerebrospinal fluid (CSF) concentrations. A 54-year-old male presented to the emergency department with generalized weakness and presumed
John F Kokai-Kun et al.
The Journal of antimicrobial chemotherapy, 64(1), 94-100 (2009-04-29)
Staphylococcus aureus infections associated with indwelling devices can be very difficult to treat due to the recalcitrant nature of bacterial biofilms to conventional antibiotics. Lysostaphin has been shown to clear S. aureus biofilms in vitro, and in this study we
Mine-Ok Chang et al.
Internal medicine (Tokyo, Japan), 51(3), 287-289 (2012-02-02)
Nafcillin is an antibiotic used for infections due to penicillin-resistant Staphylococcus aureus. In general, the adverse reactions to nafcillin have not been frequent and serious. We report here a new type of adverse reaction to nafcillin in a patient with
Thromboembolic events of mitral valve endocarditis.
Marc L Baker et al.
Cardiology journal, 17(2), 192-193 (2010-06-15)
David Buechner et al.
Journal of neurosurgery, 117(1), 103-106 (2012-05-15)
Arterial large vessel vasculopathy is an unusual complication of bacterial meningitis in adults that may result in cerebral ischemia and severe neurological sequelae. Previous therapy has included antimicrobials with no specific vascular interventions. The authors report their experience with a
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