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Merck
CN

32161

加米霉素

VETRANAL®, analytical standard

别名:

(2R,3S,4R,5S,8RR,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylohexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one

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关于此项目

经验公式（希尔记法）:
C40H76N2O12
化学文摘社编号:
145435-72-9
分子量:
777.04
MDL number:
MFCD09954125
UNSPSC Code:
41116107
NACRES:
NA.24

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SMILES string

N1([C@@H](C[C@]([C@@H](C([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C1)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O[C@@H]2O[C@@H](C[C@@H]([C@H]2O)N(C)C)C)(O)C)C)CCC

InChI

1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25?,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1

InChI key

VWAMTBXLZPEDQO-FWEXOAGLSA-N

grade

analytical standard

product line

VETRANAL®

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
veterinary

format

neat

storage temp.

2-8°C

Quality Level

100

相关类别

General description

Gamithromycin is a drug, which is administered to cattle for the treatment of bovine respiratory disease caused by Pasteurella multocida, Histophilus somni and Mannheimia haemolytica. It is also effective in treating certain infections caused by Mycoplasma.

Application

Gamithromycin may be used as a reference standard in the determination of gamithromycin in samples of plasma, lung tissue and pulmonary epithelial lining fluid using liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL2200
BCCG3892
BCCG2236
BCCB8747
BCCB3538

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访问文档库

Michal Beker et al.
Frontiers in microbiology, 9, 1329-1329 (2018-07-13)
Strains of the Pasteurellaceae bacteria Pasteurella multocida and Mannheimia haemolytica are major etiological agents of bovine respiratory disease (BRD). Treatment of BRD with antimicrobials is becoming more challenging due to the increasing occurrence of resistance in infecting strains. In Pasteurellaceae
Jase J Ball et al.
Journal of animal science, 96(3), 890-901 (2018-02-01)
Crossbred beef bulls (n = 180) were blocked by initial BW (337 ± 10.9 kg; six blocks) and assigned randomly to one of three treatments on day 0: 1) INJ; received 1 mL (100 mg Zn) of a Zn solution
Michael Kellermann et al.
Research in veterinary science, 97(2), 199-203 (2014-09-23)
This study assessed the plasma kinetics and skin/plasma concentration ratio of the azalide antibiotic gamithromycin (ZACTRAN(®), Merial) in sheep after a single subcutaneous administration at 6 mg/kg bodyweight. Gamithromycin concentrations in plasma samples collected at various intervals up to 21
Yu-Feng Zhou et al.
BMC veterinary research, 16(1), 81-81 (2020-03-07)
Gamithromycin is a macrolide approved for the treatment of bovine and swine respiratory diseases. Our study aims to establish the clinical breakpoint and optimum dose regimen for gamithromycin against Haemophilus parasuis in piglets. Gamithromycin was well absorbed and fully bioavailable
Saunders Handbook of Veterinary Drugs: Small and Large Animal (2015)
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