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经验公式(希尔记法):
C13H17N3O2
化学文摘社编号:
分子量:
247.29
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
238-133-3
MDL number:
产品名称
帕苯达唑, VETRANAL®, analytical standard
InChI
1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17)
InChI key
YRWLZFXJFBZBEY-UHFFFAOYSA-N
SMILES string
CCCCc1ccc2nc(NC(=O)OC)[nH]c2c1
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
Quality Level
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
R K Sharma et al.
Veterinary parasitology, 24(3-4), 211-220 (1987-05-01)
Adult Ascaridia galli and Heterakis gallinae obtained from the fowl (Gallus gallus) were treated in vitro with 10(-2) to 10(-5) M parbendazole and piperazine adipate for 10-60 min at 38 degrees C. Both the compounds at 10(-2) M caused mortality
E T Lyons et al.
American journal of veterinary research, 41(1), 123-124 (1980-01-01)
Critical tests were conducted in 11 naturally infected horses to evaluate the anthelmintic activity of parbendazole. Single doses at the rates of 30, 20, 10, 5, or 2.5 mg/kg of body weight were administered by stomach tube to 1, 4
D R Hennessy et al.
Journal of veterinary pharmacology and therapeutics, 8(3), 270-275 (1985-09-01)
The ability of parbendazole (PBZ) to potentiate co-administered oxfendazole (OFZ) was investigated. Administration of a range (1.35-36.0 mg/kg) of doses of PBZ with 4.53 mg OFZ/kg demonstrated that significant potentiation occurred at 4.5 mg PBZ/kg. At 4.5 mg PBZ/kg, the
M Korenaga et al.
Experimental parasitology, 55(3), 358-363 (1983-06-01)
Immunogenicity of adult Strongyloides ratti was studied in rats. Immunization of rats by intraduodenal implantation of adult worms could completely inhibit the egg production and hasten the expulsion of challenged worms which were developed from subcutaneously inoculated L3 or were
J C Havercroft et al.
Journal of cell science, 49, 195-204 (1981-06-01)
We have shown that the benzimidazole carbamate, parbendazole, is a potent inhibitor of microtubule assembly in vitro and in vivo. Radiolabelled parbendazole was shown to bind to purified tubulin. Immunofluorescence studies using antitubulin antibody showed that parbendazole effectively depolymerizes cytoplasmic
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