32451
2-Hydroxyibuprofen
VETRANAL®, analytical standard
别名:
2-[4-(2-Hydroxy-2-methylpropyl)phenyl]propionic acid
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关于此项目
经验公式（希尔记法）:
C13H18O3
化学文摘社编号:
分子量:
222.28
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3051852
InChI
1S/C13H18O3/c1-9(12(14)15)11-6-4-10(5-7-11)8-13(2,3)16/h4-7,9,16H,8H2,1-3H3,(H,14,15)
SMILES string
CC(C(O)=O)c1ccc(CC(C)(C)O)cc1
InChI key
UJHKVYPPCJBOSG-UHFFFAOYSA-N
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
General description
2-Hydroxyibuprofen is a well-known human metabolite of ibuprofen. It finds applications as a nonsteroidal and anti-inflammatory drug.
Application
2-Hydroxyibuprofen may be used as a reference standard in the determination of 2-hydroxyibuprofen in urine samples using high-performance liquid chromatography (HPLC) and ultrasound-assisted emulsification microextraction (USAEME) with ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC−MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
Simultaneous quantitative determination of the major phase I and II metabolites of ibuprofen in biological fluids by high-performance liquid chromatography on dynamically modified silica.
Kepp RD, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 696(2), 235-241 (1997)
Wastewater and Public Health: Bacterial and Pharmaceutical Exposures (2015)
Ultrasound-assisted emulsification microextraction combined with ultra-high performance liquid chromatography--tandem mass spectrometry for the analysis of ibuprofen and its metabolites in human urine.
Magiera S and Gulmez S
Journal of Pharmaceutical and Biomedical Analysis, 92(2), 193-202 (2014)
Emilia Waraksa et al.
Journal of separation science, 41(20), 3881-3891 (2018-08-14)
Ibuprofen is widely used in human and veterinary medicine for the treatment of chronic pain as well as rheumatic and musculoskeletal disorders. However, the analgesic and anti-inflammatory properties of Ibuprofen have contributed to frequent drug abuse in equestrian sports. A
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