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Merck
CN

32472

Cefquinome sulfate

VETRANAL®, analytical standard

别名:

(6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-3-(5,6,7,8-tetrahydroquinolin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate sulfate, Cefquinome sulphate

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关于此项目

经验公式（希尔记法）:
C23H24N6O5S2 · H2SO4
化学文摘社编号:
118443-89-3
分子量:
626.68
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754231
MDL number:
MFCD23381671
Beilstein/REAXYS Number:
11333438

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InChI

1S/C23H24N6O5S2.H2O4S/c1-34-27-16(14-11-36-23(24)25-14)19(30)26-17-20(31)29-18(22(32)33)13(10-35-21(17)29)9-28-8-4-6-12-5-2-3-7-15(12)28;1-5(2,3)4/h4,6,8,11,17,21H,2-3,5,7,9-10H2,1H3,(H3-,24,25,26,30,32,33);(H2,1,2,3,4)/b27-16-;/t17-,21-;/m1./s1

SMILES string

OS([O-])(=O)=O.CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(C[n+]3cccc4CCCCc34)=C(N2C1=O)C(O)=O)c5csc(N)n5

InChI key

KYOHRXSGUROPGY-OFNLCGNNSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

相关类别

General description

Cefquinome sulfates are veterinary, parenteral, fourth-generation cephalosporins belonging to the aminothiazolyl class of compounds. They exhibit broad-spectrum antimicrobial activity against gram-positive and gram-negative bacteria such as Pseudomonas aeruginosa and Enterobacteriaceae.

Application

Cefquinome sulfate may be used as an analytical reference standard for the determination of the analyte in:
  • Pharmaceutical dosage form by reversed phase high performance liquid chromatography (RP-HPLC).


It may be used as a precursor for the preparation of cefquinome that can be employed as an analytical reference standard for the analysis of the analyte in:
  • Bovine milk as well as muscle and kidney samples by HPLC and LC coupled to tandem mass spectrometry (MS/MS), respectively.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM3300
BCCH7012
BCCG5856
BCCF9184
BCCD7695

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Dongbo Li et al.
Colloids and surfaces. B, Biointerfaces, 182, 110323-110323 (2019-07-20)
Staphylococcus aureus (S. aureus) has the propensity to form biofilms, which eventually cause antibiotic resistance and treatment failure. Cefquinome sulfate (CS) is an animal-specific antibacterial agent for S. aureus infection. In this work, CS cationic proliposomes (CSCPs) were prepared by
Residue analysis of 15 penicillins and cephalosporins in bovine muscle, kidney and milk by liquid chromatography-tandem mass spectrometry.
Becker M, et al.
Analytica Chimica Acta, 520(1-2), 19-32 (2004)
Sebastian Smulski et al.
BMC veterinary research, 16(1), 99-99 (2020-04-02)
The purpose of the study described here was to evaluate the effects of different supportive treatments - such as antioxidants, immunomodulators, and nonsteroidal anti-inflammatory drugs (NSAIDs) - in mastitic cows treated with intramammary antibiotics on the efficacy of mastitis therapy
Ivana G Castilho et al.
Journal of dairy science, 100(8), 6414-6421 (2017-06-03)
Staphylococcus aureus is a common pathogen that causes subclinical bovine mastitis due to several virulence factors. In this study, we analyzed S. aureus isolates collected from the milk of cows with subclinical mastitis that had 8 possible combinations of bap
Aleksandar Siljanoski et al.
The Journal of dairy research, 85(3), 321-326 (2018-07-04)
The purpose of this study was to determine tetracycline and other antimicrobial residues in milk from dairy cows treated for clinical mastitis. Data on cow health and drugs used were obtained from the farm veterinarians. A milk sample from each
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