32473
甲氧氯普胺
VETRANAL®, analytical standard
别名:
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide, Methoxychloroprocainamide
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关于此项目
经验公式（希尔记法）:
C14H22ClN3O2
化学文摘社编号:
分子量:
299.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
206-662-9
Beilstein/REAXYS Number:
1884366
MDL number:
grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChI
1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChI key
TTWJBBZEZQICBI-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), HTR3A(3359), HTR4(3360)
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General description
Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.
Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.
Application
Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
RP?HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies.
Lamparczyk H, et al.
Biomedical Chromatography, 15(8), 513-517 (2001)
Pharmacovigilance in hospice/palliative care: rapid report of net clinical effect of metoclopramide.
David C Currow et al.
Journal of palliative medicine, 15(10), 1071-1075 (2012-08-01)
Understanding the performance of prescribed medications in day-to-day practice is important to minimize harm, maximize clinical benefits, and, eventually, better target the people who are most likely to benefit, especially in hospice/palliative care where there may be limited time to
Björn Pasternak et al.
JAMA, 310(15), 1601-1611 (2013-10-17)
Metoclopramide, a drug frequently used for nausea and vomiting in pregnancy, is thought to be safe, but information on the risk of specific malformations and fetal death is lacking. To investigate the safety of metoclopramide use in pregnancy. Register-based cohort
Determination of metoclopramide in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry.
Lee HW, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 877(18-19), 1716-1720 (2009)
A S Rao et al.
Alimentary pharmacology & therapeutics, 31(1), 11-19 (2009-11-06)
Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In 2009, the FDA issued a black box warning regarding long-term or high-dose use of this medication
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 32473-100MG | 04061826711712 |
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