32473
甲氧氯普胺
VETRANAL®, analytical standard
别名:
4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide, Methoxychloroprocainamide
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关于此项目
经验公式（希尔记法）:
C14H22ClN3O2
化学文摘社编号:
分子量:
299.80
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
206-662-9
Beilstein/REAXYS Number:
1884366
MDL number:
grade
analytical standard
Quality Level
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChI
1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
InChI key
TTWJBBZEZQICBI-UHFFFAOYSA-N
Gene Information
human ... DRD2(1813), HTR3A(3359), HTR4(3360)
General description
Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.
Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.
Application
Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.
Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.
It may also be used as an internal standard for the determination of loratadine and desloratadine in:
- Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
RP?HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies.
Lamparczyk H, et al.
Biomedical Chromatography, 15(8), 513-517 (2001)
Pharmacovigilance in hospice/palliative care: rapid report of net clinical effect of metoclopramide.
David C Currow et al.
Journal of palliative medicine, 15(10), 1071-1075 (2012-08-01)
Understanding the performance of prescribed medications in day-to-day practice is important to minimize harm, maximize clinical benefits, and, eventually, better target the people who are most likely to benefit, especially in hospice/palliative care where there may be limited time to
G S De Oliveira et al.
British journal of anaesthesia, 109(5), 688-697 (2012-09-28)
Previous evidence suggested that 10 mg systemic metoclopramide is not effective to prevent postoperative nausea and/or vomiting (PONV) in patients receiving general anaesthesia. However, the evidence included data with questioned validity by the author Yoshitaka Fujii. The objective of the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 32473-100MG | 04061826711712 |