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Merck
CN

33226

甘氨酸

99.7-101% (calc. to the dried substance), crystalline powder, suitable for IR spectroscopy, puriss. p.a., reag. Ph. Eur., buffer substance

别名:

氨基乙酸, 甘氨酸

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关于此项目

线性分子式:
NH2CH2COOH
化学文摘社编号:
56-40-6
分子量:
75.07
UNSPSC Code:
12352209
NACRES:
NA.21
PubChem Substance ID:
57648780
eCl@ss:
32160406
EC Number:
200-272-2
MDL number:
MFCD00008131
Beilstein/REAXYS Number:
635782

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产品名称

甘氨酸, puriss. p.a., reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

agency

USP/NF
reag. Ph. Eur.

grade

puriss. p.a.

assay

99.7-101% (calc. to the dried substance)

form

crystalline powder

technique(s)

IR spectroscopy: suitable

impurities

≤0.001% heavy metals (as Pb)
≤0.02% ammonium (NH4)
≤0.1% water (Karl Fischer)
≤1.0% ninhydrin-positive substances

ign. residue

≤0.05% (as SO4)

loss

≤0.5% loss on drying, 105°C, 2 h

pH

5.9-6.4 (20 °C, 5%)

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤30 mg/kg
sulfate (SO42-): ≤20 mg/kg

cation traces

Fe: ≤5 mg/kg

suitability

in accordance for identity (IR)

functional group

amine
carboxylic acid

Quality Level

200

Gene Information

rat ... Grin2a(24409)

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Application

甘氨酸可用作：
  • 一种反应物，在天然土壤粘土催化的情况下与焦棓酸发生裂解和聚合反应。
  • 一种催化剂，在芳基醛与丙二腈之间发生Knoevenagel反应C=C键。
  • 一种试剂，用于芳基亚砜类和磺胺通过迁移重排实现联芳基无金属合成。

Biochem/physiol Actions

脊髓中的抑制性神经递质，NMDA受体的变构调节器。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SDBB6099
SDBB4466
SDBB2364
SDBB2230
STBL3196

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Richard A Felix et al.
Brain structure & function, 220(5), 2639-2652 (2014-06-30)
The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Zoé Husson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)
The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory
Li-Chun Tu et al.
The EMBO journal, 32(24), 3220-3230 (2013-11-12)
Nuclear pore complexes (NPCs) mediate cargo traffic between the nucleus and the cytoplasm of eukaryotic cells. Nuclear transport receptors (NTRs) carry cargos through NPCs by transiently binding to phenylalanine-glycine (FG) repeats on intrinsically disordered polypeptides decorating the NPCs. Major impediments
Suzanne L Grant et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 844(2), 278-282 (2006-08-08)
A simple and versatile methodology using high-performance liquid chromatography (HPLC) with fluorimetric detection was developed to simultaneously determine d-serine along with other metabolically related neuroactive amino acids in the glutamatergic system: L-serine, L-glutamate, L-glutamine, and glycine. On-column sensitivity was in
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