33454
克拉维酸钾
VETRANAL®, analytical standard
别名:
棒酸钾
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关于此项目
经验公式（希尔记法）:
C8H8NO5K
化学文摘社编号:
分子量:
237.25
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
agriculture
clinical
environmental
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-8°C
SMILES字符串
[K+].[H][C@@]12CC(=O)N1[C@@H](C([O-])=O)C(\O2)=C\CO
InChI
1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
InChI key
ABVRVIZBZKUTMK-JSYANWSFSA-M
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一般描述
克拉维酸钾是奥沙那南的衍生物，属于β-内酰胺酶抑制剂。它可与青霉素类抗生素联合使用，使它们对β-内酰胺酶产生耐药性。
应用
该分析标准品可用于：
- 利用毛细管电泳（CE）结合电容耦合非接触式电导检测法，对药物制剂中的阿莫西林和克拉维酸钾（C4D）同时进行分析
- 建立一种稳定性指示的高效液相色谱（HPLC）法，并结合质谱（MS）技术，测定阿莫西林、克拉维酸钾及其杂质在其联合剂型中的含量
- 使用紫外分光光度法对克拉维酸钾和阿莫西林三水合物在其原料药、联合片剂制剂和人类尿液样本中进行残留分析
- 利用基于HPLC法的二极管阵列检测器（DAD），在静脉注射的同时测定美罗培南和克拉维酸钾及其降解杂质的含量
- 利用毛细管区带电泳法（CZE），测定联合市售出制剂中阿莫西林和克拉维酸的含量
生化/生理作用
β-内酰胺酶抑制剂，通常加入阿莫西林以提高其功效。
其他说明
有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险分类
Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
补充剂危害
储存分类代码
4.2 - Pyrophoric and self-heating hazardous materials
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
David Baunoch et al.
Infection and drug resistance, 14, 3275-3286 (2021-08-28)
Studies have shown that multiple genes influence antibiotic susceptibility, but the relationship between genotypic and phenotypic antibiotic susceptibility is unclear. We sought to analyze the concordance between the presence of antibiotic resistance (ABR) genes and antibiotic susceptibility results in urine
Jung-Whan Chon et al.
International journal of food microbiology, 165(1), 7-10 (2013-05-21)
The presence of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) in raw poultry is one of the most common factors that interfere with the isolation of Campylobacter by cefoperazone-based selective agar. The performance of modified charcoal-cefoperazone-deoxycholate agar (mCCDA) was improved
Thomas Kwong et al.
Antimicrobial agents and chemotherapy, 56(9), 4845-4855 (2012-07-04)
Streptomyces clavuligerus produces a collection of five clavam metabolites, including the clinically important β-lactamase inhibitor clavulanic acid, as well as four structurally related metabolites called 5S clavams. The paralogue gene cluster of S. clavuligerus is one of three clusters of
Winfried V Kern et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(9), 1149-1156 (2013-01-30)
This double-blind, multicenter trial compared the efficacy and safety of a single daily oral dose of moxifloxacin with oral combination therapy in low-risk febrile neutropenic patients with cancer. Inclusion criteria were cancer, febrile neutropenia, low risk of complications as predicted
Refaat B Hamed et al.
Natural product reports, 30(1), 21-107 (2012-11-09)
The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important
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