33823
癸氧喹酯
VETRANAL®, analytical standard
别名:
6-癸氧基-7-乙氧基-4-羟基-3-喹啉羧酸乙酯
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关于此项目
经验公式（希尔记法）:
C24H35NO5
化学文摘社编号:
分子量:
417.54
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
CCCCCCCCCCOc1cc2c(O)c(cnc2cc1OCC)C(=O)OCC
InChI
1S/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26)
InChI key
JHAYEQICABJSTP-UHFFFAOYSA-N
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一般描述
Decoquinate is a quinolone coccidiostat used in poultry, to retard the growth of coccidian parasites and can also show activity against Plasmodium falciparum parasite, which causes malaria in humans.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
危险声明
预防措施声明
危险分类
Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type N95 (US)
M Lallemand et al.
The Veterinary record, 159(20), 672-676 (2006-11-14)
Ninety, seven- to 10-day-old calves were allocated to three groups of 30 and treated daily for seven days with either 100 microg/kg halofuginone hydrobromide or 2.5 mg/kg decoquinate orally or left untreated as controls. The levels of diarrhoea and dehydration
Cytochrome b mutation identified in a decoquinate-resistant mutant of Toxoplasma gondii.
D C McFadden et al.
The Journal of eukaryotic microbiology, 46(5), 81S-82S (1999-10-16)
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
Nam T-G, et al.
ACS Chemical Biology, 6, 1214-1222 (2011)
M A Taylor et al.
Journal of veterinary pharmacology and therapeutics, 35(5), 417-427 (2012-06-26)
Decoquinate is a quinolone derivative that has been used for over 20 years in the control of coccidiosis in domestic ruminants. Decoquinate treats coccidiosis in lambs and calves and prevents coccidiosis in lambs when administered in feed at a dosage
Tae-Gyu Nam et al.
ACS chemical biology, 6(11), 1214-1222 (2011-08-27)
Decoquinate has single-digit nanomolar activity against in vitro blood stage Plasmodium falciparum parasites, the causative agent of human malaria. In vitro evolution of decoquinate-resistant parasites and subsequent comparative genomic analysis to the drug-sensitive parental strain revealed resistance was conferred by
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