33894
克霉唑
VETRANAL®, analytical standard
别名:
1-[（2-氯苯基）二苯基甲基]-1-H咪唑, 1-（o-氯-α，α-二苯基苄基）咪唑, 1-（o-氯三苯）咪唑
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关于此项目
经验公式（希尔记法）:
C22H17ClN2
化学文摘社编号:
分子量:
344.84
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
245-764-8
MDL number:
InChI
1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChI key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
antibiotic activity spectrum
fungi
application(s)
agriculture
environmental
format
neat
mode of action
protein synthesis | interferes
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General description
Clotrimazole, a non-toxic, systemic, imidazole derivative with broad-spectrum antimycotic activity, is primarily used in the treatment of oropharyngeal candidiasis.
Its mode of action involves the inhibition of ergosterol synthesis, which leads to structural and functional damage of the cell membrane.
Application
Clotrimazole may be used as a reference standard for the determination of the analyte in topical creams and ear drops by reversed-phase high-performance liquid chromatographic (RP-HPLC) method.
Clotrimazole may be used as an analytical reference standard for the determination of the analyte in:
- Milk samples using solid-phase extraction followed by high-performance liquid chromatography (SPE-HPLC).
- Environmental water samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis.
Machado D, et al.
Molecular and Cellular Endocrinology, 476, 17-26 (2018)
Mode of action of clotrimazole.
Iwata K, et al.
Sabouraudia, 11(2), 158-166 (1973)
SPE-HPLC method for determination of ketoconazole and clotrimazole residues in cow's milk.
Beigi KAF, et al.
Journal of the Brazilian Chemical Society, 22(9), 1679-1685 (2011)
Clotrimazole treatment for prevention of oral candidiasis in patients with acute leukemia undergoing chemotherapy: Results of a double-blind study.
Cuttner J, et al.
The American Journal of Medicine, 81(5), 771-774 (1986)
Sandra Gemma et al.
Journal of medicinal chemistry, 52(2), 502-513 (2008-12-31)
Antimalarial agents structurally based on novel pharmacophores, synthesized by low-cost synthetic procedures and characterized by low potential for developing resistance are urgently needed. Recently, we developed an innovative class of antimalarials based on a polyaromatic pharmacophore. Hybridizing the 4-aminoquinoline or
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