34002
(S)-(-)-止呕灵
VETRANAL®, analytical standard
别名:
(S)-5-氨基磺酰基-N-[(1-乙基-2-吡咯烷基)甲基]-2-甲氧基苯甲酰胺, 左舒必利
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关于此项目
经验公式（希尔记法）:
C15H23N3O4S
化学文摘社编号:
分子量:
341.43
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
产品线
VETRANAL®
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
mp
183-186 °C (lit.)
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
CCN1CCC[C@H]1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O
InChI
1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
InChI key
BGRJTUBHPOOWDU-NSHDSACASA-N
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一般描述
(S)-(−)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders.
应用
(S)-(−)-Sulpiride may be used as an analytical reference standard for the determination of the drug, in biological samples using hydrophilic interaction liquid chromatography−tandem mass spectrometry (HILIC−MS/MS) and reversed-phase high-performance liquid chromatography with fluorescence detection (HPLC-FD).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
生化/生理作用
D2 多巴胺受体拮抗剂；安定药。
法律信息
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
10 - Combustible liquids
WGK
WGK 3
个人防护装备
Eyeshields, Gloves, type N95 (US)
Levosulpiride: a review of its clinical use in psychiatry.
Mucci A, et al.
Pharmacological Research, 31(2), 95-101 (1995)
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of levosulpiride in human plasma.
Paek BI, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 809(2), 345-350 (2004)
In Bok Paek et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 809(2), 345-350 (2004-08-19)
A rapid, sensitive and selective hydrophilic interaction liquid chromatography-tandem mass spectrometric (HILIC-MS/MS) method for the determination of levosulpiride in human plasma was developed. Levosulpiride and internal standard, tiapride were extracted from human plasma with ethyl acetate at pH 11 and
Improvement and validation of a liquid chromatographic method for the determination of levosulpiride in human serum and urine.
Cho Y-H and Lee B-Y
Journal of Chromatography. B, Biomedical Sciences and Applications, 976(2), 243-251 (2003)
Hyuk Lee et al.
Journal of gastroenterology and hepatology, 22(11), 1741-1747 (2007-10-05)
This prospective study was conducted to characterize the clinical features of adult rumination syndrome, in the absence of psychiatric illness, by applying newly modified clinical criteria, and to elucidate factors influencing outcomes after treatment. Twenty-one adult patients diagnosed with rumination
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