34003
HMMNI
VETRANAL®, analytical standard
别名:
羟甲基甲硝咪唑
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关于此项目
经验公式（希尔记法）:
C5H7N3O3
化学文摘社编号:
分子量:
157.13
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
213-312-9
MDL number:
产品名称
HMMNI, VETRANAL®, analytical standard
InChI key
JSAQDPJIVQMBAY-UHFFFAOYSA-N
InChI
1S/C5H7N3O3/c1-7-4(3-9)6-2-5(7)8(10)11/h2,9H,3H2,1H3
SMILES string
Cn1c(CO)ncc1[N+]([O-])=O
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
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Application
HMMNI may be used as a reference standard for the determination of HMMNI in porcine liver using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
HMMNI may be used as an analytical reference standard for the determination of the analyte in:
- Different matrices of swine using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) and ultra-performance liquid chromatography coupled to electrospray tandem mass spectrometry (UPLC-ESI-MS/MS).
- Biological & environmental matrices using liquid chromatography with ultraviolet detection (LC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
HMMNI is a hydroxy metabolite of nitroimidazole antibiotics, belonging to a class of veterinary drugs with therapeutic applications in the treatment and prevention of certain bacterial and protozoal diseases in poultry and swine.
HMMNI is a major metabolite of nitroimidazole drug, dimetridazole (DMZ).
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Muta. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
Analytical methodologies for the determination of nitroimidazole residues in biological and environmental liquid samples: a review.
Mahugo-Santana C, et al.
Analytica Chimica Acta, 665(2), 113-122 (2010)
S Inghelbrecht et al.
Journal of veterinary pharmacology and therapeutics, 19(1), 62-67 (1996-02-01)
The anti-trichomonal efficacy and pharmacokinetics of dimetridazole were investigated in the homing pigeon (Columba livia). Dimetridazole was formulated for drinking water medication and as a prolonged-release tablet. To suppress a Trichomonas gallinae infection successfully, medicated drinking water containing dimetridazole (400
Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry.
Cannavan A and Kennedy GD
Analyst, 122(9), 963-966 (1997)
G Carignan et al.
Journal - Association of Official Analytical Chemists, 71(6), 1146-1149 (1988-11-01)
A study was conducted to monitor the elimination of dimetridazole (DMZ) and its major metabolite 2-hydroxymethyl-1-methyl-5-nitroimidazole (HMMNI) in swine plasma and tissue, using a liquid chromatographic method with electrochemical detector sensitive to 0.5 ppb. The study consisted of 2 experiments.
Determination of 5-nitroimidazoles and corresponding hydroxy metabolites in swine kidney by ultra-performance liquid chromatography coupled to electrospray tandem mass spectrometry.
Xia Xi, et al.
Analytica Chimica Acta, 637(1-2), 79-86 (2009)
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