34078
氯羟柳胺
VETRANAL®, analytical standard
别名:
2,3,5-三氯-N-(3,5-二氯-2-羟基苯基)-6-羟基苯甲酰胺, 3,3′,5,5′,6-五氯-2′-羟基水杨酰苯胺
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关于此项目
经验公式（希尔记法）:
C13H6Cl5NO3
化学文摘社编号:
分子量:
401.46
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
218-904-0
MDL number:
InChI key
JYWIYHUXVMAGLG-UHFFFAOYSA-N
InChI
1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)
SMILES string
Oc1c(Cl)cc(Cl)cc1NC(=O)c2c(O)c(Cl)cc(Cl)c2Cl
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
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General description
Oxyclozanide is an anthelmintic agent, which can show activity against Fasciola hepatica, a parasitic trematode and hence, can be used in the treatment of liver fluke infections.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Per Björk et al.
PloS one, 8(5), e63012-e63012 (2013-05-15)
S100A4 and S100A9 proteins have been described as playing roles in the control of tumor growth and metastasis. We show here that a chemical probe, oxyclozanide (OX), selected for inhibiting the interaction between S100A9 and the receptor for advanced glycation
J Mabus et al.
Journal of helminthology, 62(2), 127-132 (1988-06-01)
Laboratory hamsters (Mesocricetus auratus) were infected with Echinostoma revolutum (Trematoda). Immunoelectrophoretic studies of hamster serum showed no demonstrable antibody response to E. revolutum. Histopathologic examination of intestinal tissue of infected hamsters showed erosion of intestinal villi and lymphocytic infiltration as
B O Fagbemi et al.
Veterinary parasitology, 69(3-4), 231-240 (1997-05-01)
Antigens that were specific to Fasciola gigantica were obtained from the whole worm homogenate of the parasite by immunoaffinity chromatography in cyanogen bromide-activated sepharose 4B columns and used for the production of monoclonal antibodies. The F. gigantica-specific monoclonal antibody was
I Bremner et al.
The Veterinary record, 123(9), 217-218 (1988-08-27)
The benefits of the inclusion of cobalt and selenium supplements in anthelmintic preparations were demonstrated in a 10 week trial with cobalt- and selenium-deficient blackface wethers. The anthelmintics were based on oxfendazole and on levamisole plus oxyclozanide; three doses provided
N A Mohammed-Ali et al.
Journal of veterinary pharmacology and therapeutics, 10(2), 127-133 (1987-06-01)
The pharmacokinetics of oxyclosanide, rafoxanide and closantel were investigated in sheep (n = 5). All three drugs were extensively (greater than 99%) bound to plasma proteins and the plasma concentration/time curve was best described by a tri-exponential equation. Closantel and
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