34088
硝碘酚腈
VETRANAL®, analytical standard
别名:
4-羟基-3-碘代-5-硝基苯甲腈, 硝羟碘苄腈
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经验公式（希尔记法）:
C7H3IN2O3
化学文摘社编号:
分子量:
290.01
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
216-884-8
MDL number:
产品名称
硝碘酚腈, VETRANAL®, analytical standard
InChI key
SGKGVABHDAQAJO-UHFFFAOYSA-N
InChI
1S/C7H3IN2O3/c8-5-1-4(3-9)2-6(7(5)11)10(12)13/h1-2,11H
SMILES string
Oc1c(I)cc(cc1[N+]([O-])=O)C#N
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
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Application
Nitroxinil may be used as a reference standard in the determination of nitroxinil in veterinary active pharmaceutical ingredient manufacturing and bovine kidney using reversed-phase high-performance liquid chromatography (RP-HPLC) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Nitroxinil is an anthelmintic agent, which is also an antiparasite. It is highly effective against Fasciola species and its mode of action involves uncoupling the oxidative phosphorylation in liver flukes and also reduces spermatogenesis in surviving flukes, resulting in fewer fertile eggs.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
R Maffei Facino et al.
Arzneimittel-Forschung, 43(4), 455-460 (1993-04-01)
Liver fluke infection (Fasciola hepatica) depresses the drug-metabolizing capacity of the hepatic mixed function oxidase (MFO) and glucuronosyltransferase (GT) enzyme systems, throughout a free radicals mediated lipid peroxidation process. Glutathione (GSH, CAS 70-18-8) administered chronically (100 mg/kg i.p. once daily
C Boulard et al.
Veterinary research, 26(4), 249-255 (1995-01-01)
The responses of cattle infected with Fasciola hepatica to treatment with nitroxynil or closantel were monitored by faecal egg counts and by ELISA assay of anti-fluke antibodies. A first trial with experimentally infected heifers showed an increase in anti-fluke antibody
Multi-residue determination of phenolic and salicylanilide anthelmintics and related compounds in bovine kidney by liquid chromatography-tandem mass spectrometry.
Caldow M, et al.
Journal of Chromatography A, 1216(46), 8200-8205 (2009)
G Baziard-Mouysset et al.
Annales pharmaceutiques francaises, 54(5), 223-227 (1996-01-01)
Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl
W J Blanchflower et al.
The Analyst, 114(9), 1013-1015 (1989-09-01)
A method is described for the determination of nitroxynil residues in muscle, liver and kidney. The samples were extracted into diethyl ether and cleaned-up using a simple liquid-liquid extraction step. Any nitroxynil present was separated from interfering compounds by high-performance
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