34176
奥芬达唑
VETRANAL®, analytical standard
别名:
5-(苯亚磺酰)-苯并咪唑-2-氨基甲酸甲酯
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关于此项目
经验公式（希尔记法）:
C15H13N3O3S
化学文摘社编号:
分子量:
315.35
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
258-714-5
MDL number:
InChI
1S/C15H13N3O3S/c1-21-15(19)18-14-16-12-8-7-11(9-13(12)17-14)22(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
InChI key
BEZZFPOZAYTVHN-UHFFFAOYSA-N
SMILES string
COC(=O)Nc1nc2cc(ccc2[nH]1)S(=O)c3ccccc3
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
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General description
Oxfendazole is a benzimidazole anthelmintic drug, effective against cysticercosis, echinococcosis and fasciolosis.
Oxfendazole is a member of benzimidazole group of anthelmintics.
Application
Oxfendazole may be used as a reference standard in the determination of oxfendazole in pharmaceutical preparations using reversed-phase high-performance liquid chromatography (RP-HPLC).
Oxfendazole may be used as an analytical reference standard for the determination of the analyte in bovine liver by liquid chromatography method.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
C S Sikasunge et al.
Veterinary parasitology, 158(1-2), 57-66 (2008-10-07)
The aim of this study was to assess the effect of treating Taenia solium infected pigs with oxfendazole (OFZ) on viability and clearance of cysticerci and the corresponding persistence of specific antibody isotypes (IgG(total), IgG1, IgG2 and IgA) and circulating
L Moreno et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(10), 3819-3825 (2012-07-31)
Oxfendazole (OFZ) is efficacious for porcine cysticercosis at 30 mg/kg. OFZ is not registered to be used at this dose. The assessment of the OFZ and metabolites [(fenbendazole sulphone (FBZSO2), fenbendazole (FBZ)] plasma pharmacokinetic and tissue residue profiles after its
Chemotherapy of Gastrointestinal Helminths.
Handbook of Experimental Pharmacology, 77, 111-114 (2012)
Multi-residue method for the determination of benzimidazoles in bovine liver.
Dowling G, et al.
Analytica Chimica Acta, 529(1-2), 285-292 (2005)
Oxfendazole as successful treatment of Taenia hydatigena metacestodes in naturally infected pigs.
Gomez-Puerta LA, et al.
Asian Pacific Journal of Tropical Biomedicine, 5(11), 971-973 (2015)
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