37019
阿托品
analytical standard
别名:
(8-甲基-8-氮杂双环[3.2.1]辛-3-基) endo-(+/-)-α-(羟甲基)苯乙酸酯, 莨菪碱, 龙葵碱
等级
analytical standard
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
cleaning products
cosmetics
food and beverages
personal care
包装形式
neat
储存温度
−20°C
SMILES字符串
CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
InChI
1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?
InChI key
RKUNBYITZUJHSG-SPUOUPEWSA-N
基因信息
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131)
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一般描述
Atropine is an antimuscarinic drug, which is classified under the tropane alkaloid family of compounds.
Atropine is an antimuscarinic drug, which is classified under the tropane alkaloid family of compounds.
For the analysis of the phytotoxins.
For the analysis of the phytotoxins.
应用
Atropine may be used as a reference standard for the determination of atropine in:
- Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
- Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
- Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
- Plant materials by liquid-liquid extraction and EXtrelut® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Atropine may be used as a reference standard for the determination of atropine in:
Atropine may be used as a reference standard for the determination of atropine in:
- Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
- Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
- Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
- Plant materials by liquid-liquid extraction and EXtrelut® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.
生化/生理作用
位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。
制备说明
Dried down, ~100μg/mL after reconstitution with 1 mL of water
分析说明
purity : ≥96.0% (HPLC)
法律信息
Extrelut is a registered trademark of Merck KGaA, Darmstadt, Germany
警示用语：
Danger
危险声明
危险分类
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
Isolation of atropine and scopolamine from plant material using liquid-liquid extraction and EXtrelut columns
<BIG>Sramska P, et al.</BIG>
Journal of Chromatography. B, Biomedical Sciences and Applications, 1043, 202-208 (2017)
Are tropane alkaloids present in organic foods? Detection of scopolamine and atropine in organic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
<BIG>Cirlini M, et al.</BIG>
Food Chemistry, 239, 141-147 (2018)
High-throughput screening for drugs of abuse and pharmaceutical drugs in hair by liquid-chromatography-high resolution mass spectrometry (LC-HRMS).
<BIG>Odoardi S, et al.</BIG>
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 133, 302-310 (2017)
Enantiomeric determination and evaluation of the racemization process of atropine in Solanaceae seeds and contaminated samples by high performance liquid chromatography-tandem mass spectrometry.
<BIG>Marin-Saez J, et al.</BIG>
Journal of Chromatography A, 1474, 79-84 (2016)
Method validation for simultaneous determination of atropine, pralidoxime and 12 organophosphorus compounds in blood samples by means of high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
<BIG>Marques GLM, et al</BIG>.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1097, 44-53 (2018)
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