41694
5-Hydroxydiclofenac
analytical standard
别名:
5-OH-DCF, 2-[(2,6-Dichlorophenyl)amino]-5-hydroxybenzeneacetic acid
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关于此项目
经验公式（希尔记法）:
C14H11Cl2NO3
化学文摘社编号:
分子量:
312.15
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4199419
InChI
1S/C14H11Cl2NO3/c15-10-2-1-3-11(16)14(10)17-12-5-4-9(18)6-8(12)7-13(19)20/h1-6,17-18H,7H2,(H,19,20)
SMILES string
OC(CC1=CC(O)=CC=C1NC2=C(Cl)C=CC=C2Cl)=O
InChI key
VNQURRWYKFZKJZ-UHFFFAOYSA-N
grade
analytical standard
assay
≥97.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical
format
neat
storage temp.
−20°C
Quality Level
General description
5-Hydroxydiclofenac, a monohydroxylated metabolite of diclofenac, belongs to the class of non-steroidal anti-inflammatory compounds.29}
Application
5-Hydroxydiclofenac may be used as an analytical standard for the determination of the analyte in biological samples and wastewater by liquid chromatography (LC) based techniques.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Simultaneous determination of diclofenac, its human metabolites and microbial nitration/nitrosation transformation products in wastewaters by liquid chromatography/quadrupole-linear ion trap mass spectrometry
Osorio V, et al.
Journal of Chromatography A, 1347(1), 63-71 (2014)
High-performance liquid chromatographic determination of diclofenac and its monohydroxylated metabolites in biological fluids
Godbillon J, et al.
Journal of Chromatography. B, Biomedical Applications, 338(1), 151-159 (1985)
Jing Shi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 191, 1-7 (2017-10-02)
A novel flow injection chemiluminescence immunoassay for simple, sensitive and low-cost detection of diclofenac was established based on specific binding of antigen and antibody. Carboxylic resin beads used as solid phase carrier materials provided good biocompatibility and large surface-to-volume ratio
Simon T K Yauw et al.
Surgical infections, 19(4), 417-423 (2018-04-07)
The non-steroidal anti-inflammatory drug diclofenac has been associated with intestinal anastomotic leakage, although the underlying pathophysiology is unclear. Previous data suggest that reactivation of biliary diclofenac metabolites by microbial β-glucuronidases in the gut plays a role in harming the intestinal
C E Wilson et al.
Archives of toxicology, 92(6), 1953-1967 (2018-05-04)
The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached
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