43732
{2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid
analytical standard
别名:
Cardarine, Endurobol, GSK-516, GW 501516
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关于此项目
经验公式（希尔记法）:
C21H18F3NO3S2
化学文摘社编号:
分子量:
453.50
NACRES:
NA.24
UNSPSC Code:
41116107
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
18515150
InChI key
YDBLKRPLXZNVNB-UHFFFAOYSA-N
SMILES string
CC1=CC(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)=CC=C1OCC(O)=O
InChI
1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
grade
analytical standard
assay
≥97.0% (CHN/S), ≥97.0% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
Quality Level
General description
{2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5 thiazolyl}methylthio}phenoxy}acetic acid is a drug, which can act like a peroxisome proliferator-activated receptor agonist. It can play an important role in the regulation of central inflammation and can also be used to control brain inflammation process.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Effects of the PPAR-? agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination
Defaux A, et al.
Journal of Neuroinflammation, 6, 15-15 (2009)
Antoinette Defaux et al.
Journal of neuroinflammation, 6, 15-15 (2009-05-09)
Brain inflammation plays a central role in numerous brain pathologies, including multiple sclerosis (MS). Microglial cells and astrocytes are the effector cells of neuroinflammation. They can be activated also by agents such as interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Peroxisome proliferator-associated
Rémy Bosviel et al.
Free radical biology & medicine, 103, 146-154 (2016-12-19)
Whereas the anti-inflammatory properties and mechanisms of action of long chain ω3 PUFAs have been abundantly investigated, research gaps remain regarding the respective contribution and mechanisms of action of their oxygenated metabolites collectively known as oxylipins. We conducted a dose-dependent
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