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Merck
CN

43999

5-Hydroxyomeprazole

analytical standard

别名:

4-Methoxy-6-{[(5-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl}-5-methyl-3-pyridinemethanol, 5-Methoxy-2-{[(5-hydroxymethyl-4-methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl}-1H-benzimidazole

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关于此项目

经验公式（希尔记法）:
C17H19N3O4S
化学文摘社编号:
92340-57-3
分子量:
361.42
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329756439
MDL number:
MFCD00869771
Beilstein/REAXYS Number:
8439890

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InChI key

CMZHQFXXAAIBKE-UHFFFAOYSA-N

SMILES string

O=S(CC1=NC=C(CO)C(OC)=C1C)C2=NC3=CC(OC)=CC=C3N2

InChI

1S/C17H19N3O4S/c1-10-15(18-7-11(8-21)16(10)24-3)9-25(22)17-19-13-5-4-12(23-2)6-14(13)20-17/h4-7,21H,8-9H2,1-3H3,(H,19,20)

grade

analytical standard

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Quality Level

100

相关类别

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCP1268
BCCN4034
BCCM2380
BCCK5922
BCCJ9001

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J Olsson et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 875(1), 329-332 (2008-06-25)
The present paper demonstrates the enantiomeric separation of omeprazole and its metabolite 5-hydroxyomeprazole performed with open tubular capillary electrochromatography (OT-CEC). The protein avidin was used as the chiral selector. Avidin was immobilized by a Schiffs base type of reaction where
Valerie A Frerichs et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 824(1-2), 71-80 (2005-07-20)
A method has been developed and validated for the quantitation of midazolam, alphahydroxy-midazolam, omeprazole, and hydroxyomeprazole from one 250 microL sample of human plasma using high performance liquid chromatography coupled to tandem mass spectrometry. The method was validated for a
Ersin Gumus et al.
European journal of clinical pharmacology, 68(5), 629-636 (2011-11-15)
Lansoprazole, a cytochrome P450 2C19 (CYP2C19) substrate, has been widely used in children to manage acid-related diseases. CYP2C19 exhibits marked genetic polymorphisms, and distribution of these polymorphisms varies among different ethnic groups. There is limited data regarding the use of
B L Chen et al.
Journal of clinical pharmacology, 49(5), 574-581 (2009-04-29)
This study explores the impact of clopidogrel on the pharmacokinetics of omeprazole related to CYP2C19 genetic polymorphisms. Twelve healthy volunteers (6 CYP2C19*1/*1, 5 CYP2C19*2/*2, and 1 CYP2C19*2/*3) are enrolled in a 2-phase randomized crossover trial. In each phase, the volunteers
Marcelo Ribani et al.
Journal of chromatography. A, 1156(1-2), 201-205 (2007-02-03)
To guarantee that an analytical procedure gives reliable, exact and interpretable information about a sample, it must be validated. Two ambiguous parameters are detection limit and quantification limit. The determination of these limits is still of great concern and there
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