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Merck
CN

45160

Emetine dihydrochloride hydrate

≥99.0% (HPLC)

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关于此项目

经验公式(希尔记法):
C29H40N2O4 · 2HCl · xH2O
化学文摘社编号:
分子量:
553.56 (anhydrous basis)
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
5216794
MDL number:
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assay

≥99.0% (HPLC)

optical activity

[α]20/D +18±2°, c = 6% in H2O (dry matter)

mp

240-250 °C (dec., dry matter) (lit.)

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

O.Cl.Cl.CC[C@H]1CN2CCc3cc(OC)c(OC)cc3C2CC1C[C@H]4NCCc5cc(OC)c(OC)cc45

InChI

1S/C29H40N2O4.2ClH.H2O/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2/t18-,21-,24+,25-;;;/m0.../s1

InChI key

IZTPMTAWOCEKKM-VXMYZLRESA-N

Other Notes

Review; Inhibits protein synthesis in eucaryotes

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 1 Oral

存储类别

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品

此项目有


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Nathalie Oulhen et al.
Molecular reproduction and development, 77(1), 83-91 (2009-09-25)
Fertilization of sea urchin eggs triggers a rise of protein synthesis mainly dependent on the cap-binding protein eIF4E, which is released from its repressor 4E-BP and associates with eIF4G. Association of eIF4G with eIF4E is a crucial event for the
Claudia Colombrita et al.
Journal of neurochemistry, 111(4), 1051-1061 (2009-09-22)
Transactive response DNA-binding protein 43 (TDP-43) forms abnormal ubiquitinated and phosphorylated inclusions in brain tissues from patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. TDP-43 is a DNA/RNA-binding protein involved in RNA processing, such as transcription, pre-mRNA splicing
Dhana E Larsson et al.
Anti-cancer agents in medicinal chemistry, 12(7), 783-790 (2012-01-24)
Emetine and CGP-74514A have previously shown antitumor activity in neuroendocrine tumor cell lines. The aim of this study was to investigate the cytotoxic activity of the drugs in a three-dimensional model and to study if the mechanism of the cytotoxic
Haris Mirza et al.
Antimicrobial agents and chemotherapy, 55(2), 637-648 (2010-11-26)
Blastocystis is an emerging protistan parasite of controversial pathogenesis. Although metronidazole (Mz) is standard therapy for Blastocystis infections, there have been accumulating reports of treatment failure, suggesting the existence of drug-resistant isolates. Furthermore, very little is known about Blastocystis susceptibility
Enzymic and nonenzymic translocation by yeast polysomes. Site of action of a number of inhibitors.
A Jiménez et al.
Biochemistry, 16(21), 4727-4730 (1977-10-18)

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