Name: 红霉素
Brand: SIAL

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About This Item

经验公式（希尔记法）:

C₃₇H₆₇NO₁₃

CAS Number:

114-07-8

分子量:

733.93

Beilstein:

75279

EC 号:

204-040-1

MDL编号:

MFCD00084654

UNSPSC代码:

51282304

PubChem化学物质编号:

329756889

NACRES:

NA.76

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Agency

EPA 1694
USP/NF
tested according to Ph. Eur.

质量水平

200

表单

solid

颜色

white to faint yellow

溶解性

H₂O: soluble 2 mg/mL
acetone: freely soluble
acetonitrile: freely soluble
alcohol: soluble
amyl acetate: moderately soluble
chloroform: soluble
diethyl ether: soluble
ethyl acetate: freely soluble

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

应用

environmental

作用机制

protein synthesis | interferes

SMILES字符串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

基因信息

human ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
mouse ... Abcb1a(18671), Abcb1b(18669)

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一般描述

Chemical structure: macrolide

应用

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

包装

25g

注意

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

制备说明

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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