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Merck
CN

46738

大观霉素 二盐酸盐 五水合物

VETRANAL®, analytical standard

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关于此项目

经验公式（希尔记法）:
C14H24N2O7 · 2HCl · 5H2O
化学文摘社编号:
22189-32-8
分子量:
495.35
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329757229
EC Number:
244-554-3
Beilstein/REAXYS Number:
5684150
MDL number:
MFCD00150886

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产品名称

大观霉素 二盐酸盐 五水合物, VETRANAL®, analytical standard

InChI

1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1

InChI key

DCHJOVNPPSBWHK-UXXUFHFZSA-N

SMILES string

Cl[H].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H][C@@]12O[C@H](C)CC(=O)[C@]1(O)O[C@]3([H])[C@@H](NC)[C@@H](O)[C@@H](NC)[C@H](O)[C@@]3([H])O2

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

solubility

H2O: soluble at 

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

application(s)

clinical testing

format

neat

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

100

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相关类别

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Spectinomycin dihydrochloride pentahydrate may be used as a reference standard for the determination of spectinomycin in bovine milk samples by liquid chromatography with electrochemical detection.
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

Disclaimer

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

General description

Chemical structure: aminoglycoside

Preparation Note

Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL8956
BCCC6545

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Determination of spectinomycin residues in bovine milk using liquid chromatography with electrochemical detection.
Schermerhorn PG, et al.
Journal of Agricultural and Food Chemistry, 43(8), 2122- 2125 (1995)
Yi-Ywan M Chen et al.
Applied and environmental microbiology, 77(12), 3967-3974 (2011-05-03)
Streptococcus parasanguinis is among the most successful colonizers of the human body. Strain FW213 harbors a 7.0-kb cryptic plasmid, pFW213, with a copy number at 5 to 10 per chromosome. Sequence and functional analyses of pFW213 revealed that the open
Janice Yee Chi Lo et al.
The Journal of antimicrobial chemotherapy, 67(6), 1422-1426 (2012-02-16)
To undertake laboratory and clinical surveillance of gonococcal antimicrobial susceptibility to various therapeutic agents in Hong Kong, so as to monitor for emerging resistance and to inform on appropriate choice of empirical therapy. Trends in susceptibility of gonococci to ceftriaxone
Laurence Meslet-Cladière et al.
Eukaryotic cell, 10(12), 1670-1678 (2011-10-18)
The green alga Chlamydomonas reinhardtii today is a premier model organism for the study of green algae and plants. Yet the efficient engineering of its nuclear genome requires development of new antibiotic resistance markers. We have recoded, based on codon
Z-G Bai et al.
International journal of STD & AIDS, 23(2), 126-132 (2012-03-17)
We conducted a systematic review and meta-analysis of ceftriaxone for treatment of uncomplicated gonorrhoea compared with four other antibiotics. Thirteen randomized controlled trials (RCTs) totalling treatment of 2557 patients with uncomplicated gonorrhoea were included. Statistically significant differences were observed in
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