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Merck
CN

48912-U

ProClin 300

pkg of 50 mL, ProClin preservative for use in IVD manufacturing, CMIT/MIT 3 %

别名:

3% 5-氯-2-甲基-4-异噻唑啉-3-酮和2-甲基-4-异噻唑啉-3-酮溶液

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NACRES:
NA.21
UNSPSC Code:
12352201
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Quality Level

form

liquid

shelf life

3 yr (from Date of Manufacture)

contains

Alkyl Carboxylate

composition

CMIT/MIT, 3%

packaging

pkg of 50 mL

parameter

<45 °C operating temperature

color

colorless to light yellow

matrix

Modified glycol

operating pH range

2.5-8.5

pH

4.1 (100 g/L)

bp

189 °C

mp

-40 °C

solubility

water: soluble

density

1.03 g/cm3

General description

ProClin 防腐剂是一种的水溶性杀菌制剂,通常用于延长试剂的保质期。ProClin 300 由 3% 的 5-氯-2-甲基-4-异噻唑啉-3-酮(CMIT) 和 2-甲基-4-异噻唑啉-3-酮 (MIT) 组成,溶于含有烷基羧酸盐的无盐专有乙二醇稳定剂中。推荐工作 pH 范围为 2.5 - 8.5。

Application

ProClin 300 适用于制备不同的缓冲液,如 ELISA 缓冲液、样品和底物稀释缓冲液,用于单分子阵列(Simoa 分析)和免疫酶分析。此外,ProClin 可用于制备储存缓冲液,以储存与冠状病毒核衣壳蛋白偶联的珠子,并用于血清学多重检测。
ProClin生物杀灭防腐剂能够迅速穿透细胞膜,抑制对细胞呼吸至关重要的特定酶,因此一接触微生物有机体就会立即抑制细胞活性。ProClin的多个特定毒性位点可以防止微生物产生高水平的耐药性,使ProClin即使在IVD组份长期存储期间也保持高效。
用于IVD生产。

Biochem/physiol Actions

ProClin 产品包含例如 CMIT 和 MIT等活性物质,它们可在四个不同的检查点抑制三羧酸循环,分别为丙酮酸脱氢酶、α-酮戊二酸脱氢酶、琥珀酸脱氢酶和NADH脱氢酶。三羧酸循环的抑制可实现对细菌、真菌和酵母的有效广谱杀灭活性。

Legal Information

ProClin is a trademark of LANXESS Corp.

Disclaimer

本品不可用作全球生物杀灭剂法规监管的生物杀灭剂,法规包括但不限于:美国EPA联邦杀虫剂、杀菌剂和灭鼠剂法案,欧盟生物杀灭剂法规,加拿大有害生物管理局,土耳其生物杀灭剂法规,韩国生活化学产品以及生物杀灭剂相关安全管理法(K-BPR)等。


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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

8A - Combustible corrosive hazardous materials

flash_point_f

244.4 °F - closed cup

flash_point_c

118 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter



历史批次信息供参考:

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实验方案

The article describes the sample preparation and photometric determination of silver concentration in water samples using Spectroquant® photometers and test kits.

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货号GTIN
48912-U04061838260956