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Merck
CN

49724

丹酚酸 B

analytical standard

别名:

(2 S ,3 S )-4-[(1 E )-3-[(1 R )-1-羧基-2-（3,4-二羟基苯基）乙氧基]-3-氧代-1-丙烯-1-基]-2-（3,4-二羟基苯基）-2,3-二氢-7-羟基-3-苯并呋喃羧酸 3-[(1 R )-1-羧基-2-（3,4-二羟基苯基）乙基] 酯, 丹参酸 B, 丹芬酸 B, 紫草酸 B

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关于此项目

经验公式（希尔记法）:
C36H30O16
化学文摘社编号:
121521-90-2
分子量:
718.61
NACRES:
NA.24
PubChem Substance ID:
329757512
UNSPSC Code:
85151701
MDL number:
MFCD23115783

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InChI key

SNKFFCBZYFGCQN-VWUOOIFGSA-N

SMILES string

OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c3O[C@@H]([C@@H](C(=O)O[C@H](Cc4ccc(O)c(O)c4)C(O)=O)c23)c5ccc(O)c(O)c5

InChI

1S/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5+/t27-,28-,31+,32-/m1/s1

grade

analytical standard

assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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相关类别

General description

Salvianolic acid B is a cell protective antioxidant and free radical scavenger being investigated for a variety of conditions from ischemic heart disorders to Alzheimer′s disease.
Salvianolic acid B is one of the main water soluble bioactive components of Salvia miltiorrhiza medicinal plant, the root of which is used in the treatment of dysmenorrhea, coronary heart disease, chronic renal failure, cerebrovascular disease, hypertension, and cytotoxicity against human tumor cell lines.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Salvianolic acid B may be used as an analytical reference standard for the quantification of the anayte in the roots of Salvia miltiorrhiza and other related Chinese medicines using chromatography techniques.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: salvia

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN5543
BCCM1718
BCCJ9596
BCCH9727
BCCG9796

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Preparative isolation and purification of salvianolic acid B from the Chinese medicinal plant Salvia miltiorrhiza by high-speed counter-current chromatography
Li B-H, et al.
Journal of Chromatography A, 943(2), 235-239 (2002)
Isolation and purification of salvianolic acid A and salvianolic acid B from Salvia miltiorrhiza by high-speed counter-current chromatography and comparison of their antioxidant activity.
Sun Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 877(8-9), 733-737 (2009)
R Kasimu et al.
Chemical & pharmaceutical bulletin, 46(3), 500-504 (1998-04-29)
The dry root and rhizome of Salvia miltiorhiza (Lamiaceae) are used as a crude drug Danshen, while those of S. deserta (Xinjiang-Danshen) are mixed in Danshen at Xinjiang province when the former is in short supply. The water and MeOH
Yong-Xue Guo et al.
Journal of pharmaceutical and biomedical analysis, 43(4), 1249-1255 (2006-11-23)
The degradation of lithospermic acid B (LAB) was investigated as a function of buffer concentration, pH and temperature. Stability tests were performed using a stability-indicating high-performance liquid chromatography (HPLC) with UV-vis detection. The degradation followed pseudo-first-order kinetics under all experimental
Dae Gill Kang et al.
Life sciences, 75(15), 1801-1816 (2004-08-11)
The present study was designed to examine whether lithospermic acid B (LSB) isolated from Salvia miltiorrhiza has an ameliorative effect on renal functional parameters in association with the expression of aquaporin 2 (AQP 2) and Na,K-ATPase in the ischemia-reperfusion induced
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