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Merck
CN

50744

富马酸二甲酯

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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线性分子式:
CH3OCOCH=CHCOOCH3
化学文摘社编号:
分子量:
144.13
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
210-849-0
Beilstein/REAXYS Number:
774590
MDL number:
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产品名称

富马酸二甲酯, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

InChI

1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+

SMILES string

[H]\C(=C(\[H])C(=O)OC)C(=O)OC

InChI key

LDCRTTXIJACKKU-ONEGZZNKSA-N

grade

certified reference material
TraceCERT®

product line

TraceCERT®

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

192-193 °C (lit.)

mp

102-106 °C (lit.)

application(s)

agriculture
environmental

format

neat

Quality Level

Gene Information

human ... KEAP1(9817)

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Application

有关合适仪器技术的更多信息,请参考产品分析证书。如需进一步支持,请联系技术服务。

General description

富马酸二甲酯是一种新型口服治疗剂,可用于患有复发缓解型多发性硬化症的患者。 它显示出对面包中霉菌的有效抑制 并且还可以作为治疗牛皮癣的潜在药物(牛皮癣是一种慢性自身免疫疾病)。
该认证标准物质(CRM)根据ISO/IEC 17025ISO 17034生产和认证。该CRM可追溯来自NMI的原始材料,如NIST或NMIJ。
NMR定量信息已包括在认证内容中。证书上已给出不确定性和失效日期。
请访问http://www.sigma-aldrich.com下载您的证书。

Packaging

无底玻璃瓶。内含物在插入的融合锥体内。

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation markEnvironment

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


分析证书(COA)

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Albrecht P, et al.
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Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine?preparation of S-substituted thiosuccinic acid esters
Schmidt.JT, et al.
Bioorganic & Medicinal Chemistry, 15, 333-342 (2007)
Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure
Gimenez-Arnau A, et al.
Contact Dermatitis, 61, 249-260 (2009)
Frieder Kees
Expert opinion on pharmacotherapy, 14(11), 1559-1567 (2013-05-24)
Dimethyl fumarate (DMF) has been used as fungicide, but oral DMF activates anti-inflammatory and anti-oxidative pathways that are beneficial in the treatment of psoriasis. BG-12, a specific formulation of DMF, has been approved very recently for the treatment of relapsing-remitting
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European journal of cancer (Oxford, England : 1990), 49(17), 3708-3717 (2013-08-13)
Several autocrine soluble factors, including macrophage inflammatory protein-1α and tumour necrosis factor-alpha (TNF-α), promote the survival and growth of multiple myeloma (MM) cells. We hypothesised that inhibition of the TNF-α autocrine loop may enhance the cytotoxic effect of anticancer drugs

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