59924
聚山梨酯80
tested according to Ph. Eur.
别名:
吐温80(TWEEN® 80), 吐温 80, POE (20)山梨糖醇酐单油酸酯, 聚乙二醇山梨醇酐单油酸酯, 聚山梨酯 80, 聚氧乙烯山梨糖醇酐单油酸酯
产品名称
聚山梨酯80, tested according to Ph. Eur.
InChI
1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
SMILES string
CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
InChI key
RGPBUVUVZKQNHD-MDZDMXLPSA-N
Quality Level
agency
tested according to Ph. Eur.
vapor pressure
<1 mmHg ( 20 °C)
description
non-ionic
form
liquid
mol wt
average mol wt 79,000
aggregation number
60
refractive index
n20/D 1.472 (lit.)
CMC
0.012
transition temp
cloud point 65 °C
density
1.064 g/mL at 25 °C (lit.)
HLB
15
application(s)
research use (small molecule)
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Application
聚山梨醇酯 80 已用于药物（雷帕霉素）治疗并用于研究雷帕霉素对骨质溶解和肿瘤生长的影响。也已用于制备喷雾干燥的乳液和用于研究抗菌功效。
Biochem/physiol Actions
聚山梨酯可用作乳化剂、溶解剂和稳定剂，用于精油、局部应用和医疗输液（含静脉、皮下和肌肉给药）。
General description
聚山梨酯 80是一种表面活性剂。聚山梨酸酯是山梨醇和山梨醇酐油酸酯通过聚乙二醇链结合。
Legal Information
TWEEN is a registered trademark of Croda International PLC
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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International Journal of Food Microbiology, 229, 7-14 (2016)
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Journal of pharmaceutical sciences, 108(1), 155-161 (2018-10-14)
Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to
Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin
Abdelaziz DM, et al.
Breast Cancer Research and Treatment, 143(2), 227-237 (2014)
Relationship between Polysorbate 80 solubilization descriptors and octanol-water partition coefficients of drugs
Alvarez Nunez FA and Yalkowsky SH
International Journal of Pharmaceutics, 200(2), 217-222 (2000)
Nilsel Okudan et al.
Brain research bulletin, 165, 81-89 (2020-10-04)
Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of
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