59924
聚山梨酯80
tested according to Ph. Eur.
别名:
吐温80(TWEEN® 80), 吐温 80, POE (20)山梨糖醇酐单油酸酯, 聚乙二醇山梨醇酐单油酸酯, 聚山梨酯 80, 聚氧乙烯山梨糖醇酐单油酸酯
Agency
USP/NF
tested according to Ph. Eur.
质量水平
蒸汽压
<1 mmHg ( 20 °C)
描述
non-ionic
表单
liquid
分子量
average mol wt 79,000
聚集数
60
折射率
n20/D 1.472 (lit.)
CMC
0.012
转变温度
cloud point 65 °C
密度
1.064 g/mL at 25 °C (lit.)
HLB
15
应用
pharmaceutical (small molecule)
SMILES字符串
CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
InChI
1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+
InChI key
RGPBUVUVZKQNHD-MDZDMXLPSA-N
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一般描述
聚山梨酯 80是一种表面活性剂。聚山梨酸酯是山梨醇和山梨醇酐油酸酯通过聚乙二醇链结合。
应用
聚山梨醇酯 80 已用于药物（雷帕霉素）治疗并用于研究雷帕霉素对骨质溶解和肿瘤生长的影响。也已用于制备喷雾干燥的乳液和用于研究抗菌功效。
生化/生理作用
聚山梨酯可用作乳化剂、溶解剂和稳定剂，用于精油、局部应用和医疗输液（含静脉、皮下和肌肉给药）。
法律信息
TWEEN is a registered trademark of Croda International PLC
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves
Relationship between Polysorbate 80 solubilization descriptors and octanol-water partition coefficients of drugs
Alvarez Nunez FA and Yalkowsky SH
International Journal of Pharmaceutics, 200(2), 217-222 (2000)
Nilsel Okudan et al.
Brain research bulletin, 165, 81-89 (2020-10-04)
Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of
Priya N O Kasimbeg et al.
Journal of pharmaceutical sciences, 108(1), 155-161 (2018-10-14)
Characterizing protein aggregates in the presence of silicone oil is a long standing challenge for the pharmaceutical industry. Silicone oil is often used as a lubricant in devices that deliver and store therapeutic protein products and has been linked to
Yuan Li et al.
Frontiers in microbiology, 11, 1450-1450 (2020-07-17)
Radiation therapy is a cornerstone of modern management methods for malignancies but is accompanied by diverse side effects. In the present study, we showed that food additives such as polysorbate 80 (P80) exacerbate irradiation-induced gastrointestinal (GI) tract toxicity. A 16S
Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin
Abdelaziz DM, et al.
Breast Cancer Research and Treatment, 143(2), 227-237 (2014)
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