Merck
CN
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文件

61188

Supelco

氯沙坦钾

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别名:
2-丁基-4-氯-1-[[2′-(2H-四唑-5-基)[1,1′-联苯]-4-基]甲基]- 1H-咪唑-5-甲醇钾盐, 2-丁基-4-氯-1-{[2′-(1H-四唑-5-yl)(1,1′-联苯)-4-yl]甲基}-1H-咪唑-5-甲醇 单钾盐, DuP 753, MK 954, 钾5-(4′-((2-丁基-4-氯-5-(羟甲基)-1H-咪唑-1-基)甲基)-[1,1′-联苯]-2-yl)四唑-1-ide
经验公式（希尔记法）:
C22H22ClKN6O
CAS号:
124750-99-8
分子量:
461.00
Beilstein:
5845770
MDL编号:
MFCD02092704
PubChem化学物质编号:
329759382
NACRES:
NA.24

形式

powder or crystals

质量水平

200

保质期

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

杂质

≤0.5% water

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

SMILES string

CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)-c3ccccc3-c4nnnn4[K]

InChI

1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1

InChI key

OXCMYAYHXIHQOA-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

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相关类别

一般描述

氯沙坦钾具有长效作用，与具有利尿活性的氢氯噻嗪合用，通常会提高其效果。
氯沙坦钾是一种降压药，是血管紧张素 Ⅱ 受体 1 型阻滞剂。它可用于减少机械应力，从而控制心肌肥大的状况。

应用

有关合适的仪器技术的更多信息，请参阅产品′的检验报告。想要获得更多支持，请联系技术服务部。
氯沙坦钾可作为分析参考标准品，用于：
  • 使用反相高效液相色谱 和紫外分光光度技术，定量药物制剂中的分析物。
  • 使用液相色谱-串联质谱（LC-MS / MS）技术定量大鼠血浆中的分析物。

生化/生理作用

氯沙坦钾是一种口服、强效、选择性的竞争血管紧张素II受体1型 (AT1)拮抗剂。氯沙坦钾用于治疗高血压。

推荐产品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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示例

T1503
货号
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25G
包装规格/数量

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输入内容 1.000309185)

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索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What class of compound is Losartan Potassium, Product 61188?

    Losartan is an angiotensin II receptor antagonist that is used to treat hypertension.  It has imidazole, tetrazole, and benzene rings as part of its structure. It is anionic at neutral pH; it has a pKa in the range of 4-5.

  6. What HPLC column can I use for the analysis of Losartan in my samples?

    Losartan is commonly analyzed using a C18 RP-HPLC column.  Here at Supelco, we have successfully separated Valsartan, Losartan, and Irbesartan by HPLC chromatography on an Ascentis Express C18 15cm x 3mm column , using a mobile phase of 45:55, water:(0.1% formic acid in acetonitrile).  Run times were less than 3 minutes, with the flow rate set at 0.4 mL/min (35° C).

  7. What do you suggest for sample preparation?

    For extraction from biological fluids, consider HybridSPE - precipitation

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

LC/MS/MS method for the simultaneous estimation of losartan potassium and irbesartan in rat plasma
Prasad BGSVS, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 1(The), 206-215 (2009)
Mechanical stress-evoked but angiotensin II-independent activation of angiotensin II type 1 receptor induces cardiac hypertrophy through calcineurin pathway
Zhou N, et al
Biochemical and Biophysical Research Communications, 397, 263-269 (2010)
Christopher J Haddock et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(6), R1027-R1035 (2020-04-16)
There are examples of physiological conditions under which thirst is inappropriately exaggerated, and the mechanisms for these paradoxical ingestive behaviors remain unknown. We are interested in thirst mechanisms across the female life cycle and have identified a novel mechanism through
Simultaneous determination of losartan and hydrochlorothiazide in tablets by high-performance liquid chromatography
Carlucci G, et al.
Journal of Pharmaceutical and Biomedical Analysis, 23(1), 185-189 (2000)
Michael D Kim et al.
ERJ open research, 7(1) (2021-02-04)
The aim was to determine whether losartan reduces cigarette smoke (CS)-induced airway inflammation and mucus hypersecretion in an in vitro model and a small clinical trial. Primary human bronchial epithelial cells (HBECs) were differentiated at the air-liquid interface (ALI) and
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