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Merck
CN

61739

Sigma-Aldrich

N-月桂酰肌氨酸

≥98.0% (GC), suitable for protein quantification, purum p.a.

别名:

N-十二烷酰基-N-甲基甘氨酸, 肌氨酰 L

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关于此项目

线性分子式:
CH3(CH2)10CON(CH3)CH2COOH
CAS Number:
97-78-9
分子量:
271.40
Beilstein:
1792084
EC 号:
202-608-3
MDL编号:
MFCD00021749
UNSPSC代码:
12352100
PubChem化学物质编号:
57651861
NACRES:
NA.21

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Product Name

N-月桂酰肌氨酸, purum p.a., ≥98.0% (GC)

描述

anionic

质量水平

200

等级

purum p.a.

方案

≥98.0% (GC)

分子量

271.40 g/mol

技术

protein quantification: suitable

杂质

≤0.2% water

灼烧残渣

≤0.1%

mp

45-50 °C

痕量阴离子

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤100 mg/kg

痕量阳离子

Ca: ≤20 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤70 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤20 mg/kg

官能团

amide
carboxylic acid

SMILES字符串

CCCCCCCCCCCC(=O)N(C)CC(O)=O

InChI

1S/C15H29NO3/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19/h3-13H2,1-2H3,(H,18,19)

InChI key

BACYUWVYYTXETD-UHFFFAOYSA-N

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相关类别

一般描述

N-月桂酰肌氨酸（N-十二烷酰基-N-甲基甘氨酸，Sarkosyl L，LS）是一种阴离子表面活性剂。已经研究了其在小鼠模型中对单纯疱疹病毒2型（HSV-2）阴道内感染的杀伤作用。

应用

N-月桂酰肌氨酸可用作透皮制剂中的透皮增强剂，因为它能够增强皮肤角质层脂质结构的流动性†

象形图

Skull and crossbonesCorrosion
GHS06,GHS05

警示用语：

Danger

危险声明

H315,H318,H330

危险分类

Acute Tox. 2 Inhalation - Eye Dam. 1 - Skin Irrit. 2

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCG8849
BCCG5961
BCCG6616
BCCG6241
BCCG0145

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Yeu-Chun Kim et al.
International journal of pharmaceutics, 352(1-2), 129-138 (2007-12-15)
To develop formulations for transdermal drug delivery, this study tested the hypothesis that the anionic surfactant, N-lauroylsarcosine (NLS), and ethanol synergistically increase skin permeability by increasing the fluidity of stratum corneum lipid structure. Skin permeability experiments showed that transdermal delivery
Kunie Ando et al.
The American journal of pathology, 178(2), 803-816 (2011-02-02)
Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau. Because murine tau might interfere with the toxic effects of human mutant tau, we generated a
Yoshiaki Furukawa et al.
The Journal of biological chemistry, 286(21), 18664-18672 (2011-04-02)
The transactivation response element (TAR) DNA-binding protein-43 (TDP-43) is a nuclear protein that normally regulates transcription and splicing. Abnormal accumulation of insoluble inclusions containing TDP-43 has been recently reported in the affected tissues of amyotrophic lateral sclerosis (ALS) patients. Here
S Roy et al.
Antimicrobial agents and chemotherapy, 45(6), 1671-1681 (2001-05-17)
The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS
Jian Sun et al.
Nucleic acids research, 43(14), 6827-6846 (2015-07-04)
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation
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