63184
伊红-5-马来酰亚胺
suitable for fluorescence, ≥93% (HPLC)
别名:
EMA, 伊红-5-马来酰亚胺
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关于此项目
经验公式（希尔记法）:
C24H9Br4NO7
化学文摘社编号:
分子量:
742.95
MDL编号:
UNSPSC代码:
12352207
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥93% (HPLC)
荧光
λex 524 nm; λem 545 nm (after derivatization with 2-mercaptoethanol)
适用性
suitable for fluorescence
储存温度
2-8°C
SMILES字符串
Oc1c(Br)cc2c(Oc3c(Br)c(O)c(Br)cc3C24OC(=O)c5cc(ccc45)N6C(=O)C=CC6=O)c1Br
InChI
1S/C24H9Br4NO7/c25-13-6-11-21(17(27)19(13)32)35-22-12(7-14(26)20(33)18(22)28)24(11)10-2-1-8(5-9(10)23(34)36-24)29-15(30)3-4-16(29)31/h1-7,32-33H
InChI key
YRCLWXRIEYQTAV-UHFFFAOYSA-N
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一般描述
5-马来酰亚胺-伊红，也称为 EMA 或伊红-5-马来酰亚胺，是一种荧光结合剂。5-马来酰亚胺-伊红结合试验可测量 EMA 标记细胞减少的平均通道荧光（MCF）读数。
应用
伊红-5-马来酰亚胺已被用作人红细胞带 3 蛋白的荧光探针。 它被广泛用作实验室诊断探针，以通过流式细胞术检测遗传性球形红细胞增多症（HS）。 伊红-5-马来酰亚胺结合试验已用于分析阿勒替尼（一线治疗）对于变性淋巴瘤激酶（ALK）的效果。
其他说明
三重探针。测量蛋白质在溶液和膜中的旋转扩散，包括肌球蛋白和丙酮酸脱氢酶
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A J Visser et al.
European journal of biochemistry, 121(1), 233-235 (1981-12-01)
The enzymatically reduced lipoyl residues of the transacetylase component of the pyruvate dehydrogenase complex from Escherichia coli were labeled with eosin maleimide. Using eosin as triplet probe, triplet-triplet absorption dichroism measurements were performed to obtain rotational correlation times of the
S Ishiwata et al.
The Journal of biological chemistry, 262(17), 8314-8317 (1987-06-15)
We studied the rotational Brownian motions of myosin heads, of which the sulfhydryl group was selectively labeled with the triplet probe 5-eosinylmaleimide, in myofibril by using flash-induced phosphorescence anisotropy decay measurements. The anisotropy decay curve under relaxing conditions consisted of
Renée L Crisp et al.
Pediatric blood & cancer, 59(7), 1299-1301 (2012-04-11)
We studied 31 children with hemolytic anemia, or with positive family history for hereditary spherocytosis (HS), to assess the reliability of capillary blood samples for the diagnosis. HS was diagnosed in 20 patients. Cryohemolysis (CH) was positive in 94% and
Linda Hunt et al.
Cytometry. Part B, Clinical cytometry, 88(1), 50-57 (2014-09-18)
The eosin-5'-maleimide (EMA) Binding test measures reduced mean channel fluorescence (MCF) reading of EMA-labeled red cells (EMA-RBCs) from patients with hereditary spherocytosis (HS). Reporting test results can be either in the actual MCF reading or as a ratio by normalization
James A Kuzich et al.
Pathology, 53(5), 608-612 (2021-02-24)
We reviewed haematological investigations for 43 patients treated at a single centre with alectinib, an inhibitor of anaplastic lymphoma kinase (ALK) which is considered standard first-line treatment for patients with ALK-rearranged advanced non-small cell lung cancer. Ninety-five percent of patients
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