63184
伊红-5-马来酰亚胺
suitable for fluorescence, ≥93% (HPLC)
别名:
EMA, 伊红-5-马来酰亚胺
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关于此项目
经验公式（希尔记法）:
C24H9Br4NO7
化学文摘社编号:
分子量:
742.95
MDL编号:
UNSPSC代码:
12352207
PubChem化学物质编号:
NACRES:
NA.32
质量水平
方案
≥93% (HPLC)
表单
powder
分子量
742.95 g/mol
颜色
light orange to dark orange
light red
荧光
λex 524 nm; λem 545 nm (after derivatization with 2-mercaptoethanol)
适用性
suitable for fluorescence
储存温度
2-8°C
SMILES字符串
Oc1c(Br)cc2c(Oc3c(Br)c(O)c(Br)cc3C24OC(=O)c5cc(ccc45)N6C(=O)C=CC6=O)c1Br
InChI
1S/C24H9Br4NO7/c25-13-6-11-21(17(27)19(13)32)35-22-12(7-14(26)20(33)18(22)28)24(11)10-2-1-8(5-9(10)23(34)36-24)29-15(30)3-4-16(29)31/h1-7,32-33H
InChI key
YRCLWXRIEYQTAV-UHFFFAOYSA-N
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一般描述
5-马来酰亚胺-伊红，也称为 EMA 或伊红-5-马来酰亚胺，是一种荧光结合剂。5-马来酰亚胺-伊红结合试验可测量 EMA 标记细胞减少的平均通道荧光（MCF）读数。
应用
伊红-5-马来酰亚胺已被用作人红细胞带 3 蛋白的荧光探针。 它被广泛用作实验室诊断探针，以通过流式细胞术检测遗传性球形红细胞增多症（HS）。 伊红-5-马来酰亚胺结合试验已用于分析阿勒替尼（一线治疗）对于变性淋巴瘤激酶（ALK）的效果。
其他说明
三重探针。测量蛋白质在溶液和膜中的旋转扩散，包括肌球蛋白和丙酮酸脱氢酶
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
A J Visser et al.
European journal of biochemistry, 121(1), 233-235 (1981-12-01)
The enzymatically reduced lipoyl residues of the transacetylase component of the pyruvate dehydrogenase complex from Escherichia coli were labeled with eosin maleimide. Using eosin as triplet probe, triplet-triplet absorption dichroism measurements were performed to obtain rotational correlation times of the
S Ishiwata et al.
The Journal of biological chemistry, 262(17), 8314-8317 (1987-06-15)
We studied the rotational Brownian motions of myosin heads, of which the sulfhydryl group was selectively labeled with the triplet probe 5-eosinylmaleimide, in myofibril by using flash-induced phosphorescence anisotropy decay measurements. The anisotropy decay curve under relaxing conditions consisted of
P Joshi et al.
International journal of laboratory hematology, 38(5), 520-526 (2016-06-25)
Laboratory diagnosis of hereditary spherocytosis (HS) relies on increased incubated red cell osmotic fragility test for screening. We evaluated the diagnostic role of eosin-5'-maleimide (EMA) binding test by flow cytometry in spherocytic and microcytic hypochromic hematological disorders in North Indians.
Linda Hunt et al.
Cytometry. Part B, Clinical cytometry, 88(1), 50-57 (2014-09-18)
The eosin-5'-maleimide (EMA) Binding test measures reduced mean channel fluorescence (MCF) reading of EMA-labeled red cells (EMA-RBCs) from patients with hereditary spherocytosis (HS). Reporting test results can be either in the actual MCF reading or as a ratio by normalization
James A Kuzich et al.
Pathology, 53(5), 608-612 (2021-02-24)
We reviewed haematological investigations for 43 patients treated at a single centre with alectinib, an inhibitor of anaplastic lymphoma kinase (ALK) which is considered standard first-line treatment for patients with ALK-rearranged advanced non-small cell lung cancer. Ninety-five percent of patients
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