67028
甲基乙二醛 溶液
technical, ~40% in H2O
别名:
2-氧代丙醛, Pyruvaldehyde, 丙酮醛
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关于此项目
线性分子式:
CH3COCHO
化学文摘社编号:
分子量:
72.06
Beilstein:
906750
MDL编号:
UNSPSC代码:
12352100
PubChem化学物质编号:
NACRES:
NA.22
等级
technical
质量水平
浓度
~40% in H2O
密度
1.19 g/mL at 20 °C
官能团
aldehyde
ketone
储存温度
2-8°C
SMILES字符串
[H]C(=O)C(C)=O
InChI
1S/C3H4O2/c1-3(5)2-4/h2H,1H3
InChI key
AIJULSRZWUXGPQ-UHFFFAOYSA-N
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一般描述
甲基乙二醛是糖酵解的一种有毒内源性副产物。它是一种反应性二羰基化合物，可促进蛋白质的非酶糖基化作用以产生不可逆的高级糖基化终产物，从而导致蛋白质的交联或降解。
应用
甲基乙二醛溶液可用于细胞毒性研究。
警示用语：
Danger
危险分类
Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Potential Neuroprotective and Anti-Apoptotic Properties of a Long-Lasting Stable Analog of Ghrelin: an In Vitro Study Using SH-SY5Y Cells.
Popelova A, et al.
Physiological Research, 67(2), 339-346 (2018)
Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1, 2-diamino-4, 5-methylenedioxybenzene.
Ogasawara Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1029, 102-105 (2016)
Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors.
Al?Balas Q A, et al.
Drug Development Research, 79(2), 58-69 (2018)
Naila Ahmed et al.
Investigative ophthalmology & visual science, 44(12), 5287-5292 (2003-11-26)
To determine the concentrations of methylglyoxal-derived advanced glycation end-products (AGEs), the hydroimidazolones MG-H1 and -H2, in soluble human lens proteins and compare them with the concentrations of other methylglyoxal-derived AGEs and pentosidine. Lens protein samples were hydrolyzed enzymatically. AGEs were
P Seppänen et al.
Biochimica et biophysica acta, 674(2), 169-177 (1981-05-05)
1. Putrescine and spermidine depletion produced by alpha-difluoromethylornithine, an irreversible inhibitor or ornithine decarboxylase (EC 4.1.1.17), resulted in a strikingly enhanced cellular uptake of methylglyoxal bis(guanylhydrazone) in cultured Ehrlich ascites carcinoma cells and human lymphocytic leukemia cells. 2. A prior
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