67028
甲基乙二醛 溶液
technical, ~40% in H2O
别名:
2-氧代丙醛, Pyruvaldehyde, 丙酮醛
等级
technical
质量水平
浓度
~40% in H2O
密度
1.19 g/mL at 20 °C
官能团
aldehyde
ketone
储存温度
2-8°C
SMILES字符串
[H]C(=O)C(C)=O
InChI
1S/C3H4O2/c1-3(5)2-4/h2H,1H3
InChI key
AIJULSRZWUXGPQ-UHFFFAOYSA-N
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一般描述
甲基乙二醛是糖酵解的一种有毒内源性副产物。它是一种反应性二羰基化合物，可促进蛋白质的非酶糖基化作用以产生不可逆的高级糖基化终产物，从而导致蛋白质的交联或降解。
应用
甲基乙二醛溶液可用于细胞毒性研究。
警示用语：
Danger
危险分类
Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
储存分类代码
8A - Combustible corrosive hazardous materials
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Popelova A, et al.
Physiological Research, 67(2), 339-346 (2018)
Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1, 2-diamino-4, 5-methylenedioxybenzene.
Ogasawara Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1029, 102-105 (2016)
Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors.
Al?Balas Q A, et al.
Drug Development Research, 79(2), 58-69 (2018)
Naila Ahmed et al.
Investigative ophthalmology & visual science, 44(12), 5287-5292 (2003-11-26)
To determine the concentrations of methylglyoxal-derived advanced glycation end-products (AGEs), the hydroimidazolones MG-H1 and -H2, in soluble human lens proteins and compare them with the concentrations of other methylglyoxal-derived AGEs and pentosidine. Lens protein samples were hydrolyzed enzymatically. AGEs were
Nicole Schupp et al.
Annals of the New York Academy of Sciences, 1043, 685-695 (2005-07-23)
In patients with chronic renal failure, cancer incidence is increased. This may be related to an elevated level of genomic damage, which has been demonstrated by micronuclei formation as well as by comet assay analysis. Advanced glycation end products (AGEs)
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