67028
甲基乙二醛 溶液
technical, ~40% in H2O
别名:
2-氧代丙醛, Pyruvaldehyde, 丙酮醛
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关于此项目
线性分子式:
CH3COCHO
化学文摘社编号:
分子量:
72.06
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
906750
产品名称
甲基乙二醛 溶液, technical, ~40% in H2O
InChI
1S/C3H4O2/c1-3(5)2-4/h2H,1H3
SMILES string
[H]C(=O)C(C)=O
InChI key
AIJULSRZWUXGPQ-UHFFFAOYSA-N
grade
technical
concentration
~40% in H2O
density
1.19 g/mL at 20 °C
functional group
aldehyde
ketone
storage temp.
2-8°C
Quality Level
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Application
甲基乙二醛溶液可用于细胞毒性研究。
General description
甲基乙二醛是糖酵解的一种有毒内源性副产物。它是一种反应性二羰基化合物，可促进蛋白质的非酶糖基化作用以产生不可逆的高级糖基化终产物，从而导致蛋白质的交联或降解。
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors.
Al?Balas Q A, et al.
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Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1, 2-diamino-4, 5-methylenedioxybenzene.
Ogasawara Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1029, 102-105 (2016)
P Seppänen et al.
Biochimica et biophysica acta, 674(2), 169-177 (1981-05-05)
1. Putrescine and spermidine depletion produced by alpha-difluoromethylornithine, an irreversible inhibitor or ornithine decarboxylase (EC 4.1.1.17), resulted in a strikingly enhanced cellular uptake of methylglyoxal bis(guanylhydrazone) in cultured Ehrlich ascites carcinoma cells and human lymphocytic leukemia cells. 2. A prior
Nicole Schupp et al.
Annals of the New York Academy of Sciences, 1043, 685-695 (2005-07-23)
In patients with chronic renal failure, cancer incidence is increased. This may be related to an elevated level of genomic damage, which has been demonstrated by micronuclei formation as well as by comet assay analysis. Advanced glycation end products (AGEs)
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